Coexistence of Avian Influenza Virus H10 and H9 Subtypes among Chickens in Live Poultry Markets during an Outbreak of Infection with a Novel H10N8 Virus in Humans in Nanchang, China

Maohong Hu; Xiaodan Li; Xiansheng Ni; Jingwen Wu; Rongbao Gao; Wen Xia; Dayan Wang; Fenglan He; Shengen Chen; Yangqing Liu; Shuangli Guo; Hui Li; Yuelong Shu; Jeffrey W. Bethel; Mingbin Liu; Justin B. Moore; Haiying Chen

doi:10.7883/yoken.JJID.2014.377

Original Article

Coexistence of Avian Influenza Virus H10 and H9 Subtypes among Chickens in Live Poultry Markets during an Outbreak of Infection with a Novel H10N8 Virus in Humans in Nanchang, China

Maohong Hu, Xiaodan Li, Xiansheng Ni, Jingwen Wu, Rongbao Gao, Wen Xia, Dayan Wang, Fenglan He, Shengen Chen, Yangqing Liu, Shuangli Guo, Hui Li, Yuelong Shu, Jeffrey W. Bethel, Mingbin Liu, Justin B. Moore, Haiying Chen

Author information

Maohong Hu
Nanchang Center for Disease Control and Prevention
Xiaodan Li
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission
Xiansheng Ni
Nanchang Center for Disease Control and Prevention
Jingwen Wu
Nanchang Center for Disease Control and Prevention
Rongbao Gao
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission
Wen Xia
Nanchang Center for Disease Control and Prevention
Dayan Wang
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission
Fenglan He
Nanchang Center for Disease Control and Prevention
Shengen Chen
Nanchang Center for Disease Control and Prevention
Yangqing Liu
Nanchang Center for Disease Control and Prevention
Shuangli Guo
Nanchang Center for Disease Control and Prevention
Hui Li
Nanchang Center for Disease Control and Prevention
Yuelong Shu
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission
Jeffrey W. Bethel
School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University
Mingbin Liu
Nanchang Center for Disease Control and Prevention
Justin B. Moore
Department of Health Promotion, Education & Behavior & Office of Public Health Practice and Community Engagement, Arnold School of Public Health, University of South Carolina
Haiying Chen
Nanchang Center for Disease Control and Prevention

Keywords: avian influenza, influenza virus, live poultry market, surveillance

JOURNAL FREE ACCESS

2015 Volume 68 Issue 5 Pages 364-369

DOI https://doi.org/10.7883/yoken.JJID.2014.377

Browse “Advance online publication” version

Details

Abstract

Infection with the novel H10N8 virus in humans has raised concerns about its pandemic potential worldwide. We report the results of a cross-sectional study of avian influenza viruses (AIVs) in live poultry markets (LPMs) in Nanchang, China, after the first human case of H10N8 virus infection was reported in the city. A total of 201 specimens tested positive for AIVs among 618 samples collected from 24 LPMs in Nanchang from December 2013 to January 2014. We found that the LPMs were heavily contaminated by AIVs, with H9, H10, and H5 being the predominant subtypes and more than half of the LPMs providing samples that were positive for the H10 subtype. Moreover, the coexistence of different subtypes was common in LPMs. Of the 201 positive samples, 20.9% (42/201) had mixed infections with AIVs of different HA subtypes. Of the 42 mixed infections, 50% (21/42) showed the coexistence of the H9 and H10 subtypes, with or without H5, and were from chicken samples. This indicated that the H10N8 virus probably originated from segment reassortment of the H9 and H10 subtypes.

Corresponding author

Register with J-STAGE for free!