Fungerin, a Fungal Alkaloid, Arrests the Cell Cycle in M Phase by Inhibition of Microtubule Polymerization
2004 Volume 57 Issue 7 Pages 415-420
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2004 Volume 57 Issue 7 Pages 415-420
A fungal alkaloid fungerin was found to arrest the cell cycle of Jurkat cells at the G2/M phase, then to induce apoptosis. Immunoblotting showed that fungerin led to hyperphosphorylation for Cdc25C and dephosphorylation of Cdc2, indicating that the compound arrests the cell cycle at the M phase. Moreover, fungerin inhibited the polymerization of microtubule proteins in vitro. It was concluded that fungerin arrests the cell cycle at the M phase through inhibition of microtubule polymerization.
