The Novel Gluconeogenesis Inhibitors FR225659 and Related Compounds that Originate from Helicomyces sp. No. 19353 II. Biological Profiles

YOSHIHIRO OHTSU; HIROMI SASAMURA; TOSHIHIRO SHIBATA; HIDENORI NAKAJIMA; MOTOHIRO HINO; TAKASHI FUJII

doi:10.7164/antibiotics.56.689

The Novel Gluconeogenesis Inhibitors FR225659 and Related Compounds that Originate from Helicomyces sp. No. 19353

II. Biological Profiles

YOSHIHIRO OHTSU, HIROMI SASAMURA, TOSHIHIRO SHIBATA, HIDENORI NAKAJIMA, MOTOHIRO HINO, TAKASHI FUJII

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JOURNAL FREE ACCESS

2003 Volume 56 Issue 8 Pages 689-693

DOI https://doi.org/10.7164/antibiotics.56.689

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Abstract

The novel gluconeogenesis inhibitor FR225659 and four related compounds were isolated from the cultured broth of a fungal strain No. 19353. These compounds inhibited the glucagon-stimulated gluconeogenesis of rat primary hepatocytes and had hypoglycemic effects in two different in vivo models.

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