Adxanthromycins A and B, New Inhibitors of ICAM-1/LFA-1 Mediated Cell Adhesion Molecule from Streptomyces sp. NA-148 II. Physico-chemical Properties and Structure Elucidation

SENJI TAKAHASHI; TAKAYUKI NAKANO; TSUKASA KOIWA; TOSHIRO NOSHITA; SHINJI FUNAYAMA; HIROYUKI KOSHINO; AKIRA NAKAGAWA

doi:10.7164/antibiotics.53.163

Adxanthromycins A and B, New Inhibitors of ICAM-1/LFA-1 Mediated Cell Adhesion Molecule from Streptomyces sp. NA-148

II. Physico-chemical Properties and Structure Elucidation

SENJI TAKAHASHI, TAKAYUKI NAKANO, TSUKASA KOIWA, TOSHIRO NOSHITA, SHINJI FUNAYAMA, HIROYUKI KOSHINO, AKIRA NAKAGAWA

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JOURNAL FREE ACCESS

2000 Volume 53 Issue 2 Pages 163-170

DOI https://doi.org/10.7164/antibiotics.53.163

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Abstract

Adxanthromycins A and B are new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule isolated from the fermentation broth of Streptomyces sp. NA-148. The molecular formula of adxanthromycins A and B were determined as C₄₂H₄₀O₁₇ and C₄₈H₅₀O₂₂, respectively by FAB-MS and NMR spectral analyses, and the structures of both compounds were elucidated to be a dimeric anthrone peroxide skeleton containing α-D-galactose by various NMR spectral analyses and chemical degradation.

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