The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
GE3, a Novel Hexadepsipeptide Antitumor Antibiotic, Produced by Streptomyces sp.
I. Taxonomy, Production, Isolation, Physico-chemical Properties, and Biological Activities
YASUSHI SAKAI, TETSUO YOSHIDA, TETSUYA TSUJITA, KEIKO OCHIAI, TSUTOMU AGATSUMA, YUTAKA SAITOH, FUTOSHI TANAKA, TADAKAZU AKIYAMA, SHIRO AKINAGA, TAMIO MIZUKAMI
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1997 Volume 50 Issue 8 Pages 659-664

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Abstract

GE3, a novel cyclic hexadepsipeptide antibiotic, was isolated from the culture broth of Streptomyces sp. GE3. GE3 was weakly active against some Gram-positive and Gram-negative bacteria and showed potent cytotoxicity against human tumor cell lines. GE3 also exhibited antitumor activity against human pancreatic carcinoma, PSN-1, in vivo. GE3B, a linear peptide form of GE3, which was isolated from the same culture broth with GE3, showed no antibiotic and cytotoxic activities, suggesting the necessity of the cyclic structure of GE3 for its biological activities.

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The Journal of Antibiotics, Series A

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