Antascomicins A, B, C, D and E Novel FKBP12 Binding Compounds from a Micromonospora Strain

THEODOR FEHR; JEAN-JACQUES SANGLIER; WALTER SCHULER; LILIANE GSCHWIND; MONIQUE PONELLE; WOLFGANG SCHILLING; CATHERINE WLOLAND

doi:10.7164/antibiotics.49.230

Antascomicins A, B, C, D and E Novel FKBP12 Binding Compounds from a Micromonospora Strain

THEODOR FEHR, JEAN-JACQUES SANGLIER, WALTER SCHULER, LILIANE GSCHWIND, MONIQUE PONELLE, WOLFGANG SCHILLING, CATHERINE WLOLAND

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JOURNAL FREE ACCESS

1996 Volume 49 Issue 3 Pages 230-233

DOI https://doi.org/10.7164/antibiotics.49.230

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Abstract

5 novel ascomycin-like compounds, antascomicins A, B, C, D and E were isolated from a strain of Micromonospora. The antascomicins bind strongly to the FK506-binding protein FKBP12 and antagonize the immunosuppressive activity of FK506 and rapamycin. The strain description, fermentation, structure elucidation and biological activity of these compounds are described.

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