CALBISTRINS, NOVEL ANTIFUNGAL AGENTS PRODUCED BY Penicillium restrictum II. ISOLATION AND ELUCIDATION OF STRUCTURE

GREGORY M. BRILL; RANDAL H. CHEN; RONALD R. RASMUSSEN; DAVID N. WHITTERN; JAMES B. MCALPINE

doi:10.7164/antibiotics.46.39

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

CALBISTRINS, NOVEL ANTIFUNGAL AGENTS PRODUCED BY Penicillium restrictum

II. ISOLATION AND ELUCIDATION OF STRUCTURE

GREGORY M. BRILL, RANDAL H. CHEN, RONALD R. RASMUSSEN, DAVID N. WHITTERN, JAMES B. MCALPINE

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 1 Pages 39-47

DOI https://doi.org/10.7164/antibiotics.46.39

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Abstract

The novel antifungal agents, calbistrins A, B, C and D have been isolated from a strain of Penicillium restrictum (AB 1875C-28). The four congeners were separated by bioactivity directed fractionation using countercurrent chromatography and preparative-HPLC. NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system.

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