The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
PARVODICIN, A NOVEL GLYCOPEPTIDE FROM A NEW SPECIES, ACTINOMADURA PARVOSATA: DISCOVERY, TAXONOMY, ACTIVITY AND STRUCTURE ELUCIDATION
SIEGFRIED B. CHRISTENSEN, H. S. ALLAUDEEN, MICHAEL R. BURKE, STEVEN A. CARR, S. K. CHUNG, PETER DEPHILLIPS, JOHN J. DINGERDISSEN, MICHAEL DIPAOLO, ALBERT J. GIOVENELLA, SARAH L. HEALD, LEWIS B. KILLMER, BRUCE A. MICO, LUCIANO MUELLER, CHARLES H. PAN, BENJAMIN L. POEHLAND, JAMES B. RAKE, GERALD D. ROBERTS, MARCIA C. SHEARER, ROBERT D. SITRIN, Louis J. NISBET, PETER W. JEFFS
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1987 Volume 40 Issue 7 Pages 970-990

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Abstract

An extensive taxonomic investigation identified strain SK&F-AAJ-271 as a new species, designated Actinomadura parvosata. Fermentations of this organism produce a complex of acidic, lipophilic glycopeptide antibiotics, the parvodicins. Structures for seven of the isolated components were derived from a combination of mass spectral, high-field NMR and chemical techniques. The O-acetyl functionality present in two of the isolated components is a structural feature unique among the known members of this class of antibiotics. The parvodicins are active in vitro against a range of Gram-positive bacteria. The most active parvodicin, C1, produces high serum levels in vivo and has the potential for a long duration of action.

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The Journal of Antibiotics, Series A

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