The 1,8 - Naphthalimide derivatives are widely used in the synthesis of anticancer drugs. The activity of these compounds embed in DNA has been tested and the results are very good. In recent years, many scientists have devoted themselves to the study of new synthetic methods of synthesizing of 1,8 - Naphthalimide derivatives. It has been found that these compounds embedded in breast cancer cells, colorectal cancer cells, and lung cancer cells very well. We designed two series of derivatives and hope to further study their applications in the future.