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  • 學位論文

合成具有抗癌藥物潛力的1,8-萘醯亞胺衍生物

Synthesis of 1,8 - Naphthalimide derivatives for potential anticancer drugs

指導教授 : 施增廉

摘要


1,8-萘醯亞胺類衍生物廣泛的應用於合成抗癌藥物,這類化合物與DNA嵌合活性經過測試得到結果很好,已研究出對於乳腺癌、結腸直腸癌、肺癌細胞活性良好。近年來,許多科學家致力研究新的合成方式來合成1,8-萘醯亞胺類衍生物,而我們也設計了兩系列的衍生物,期望未來能進一步研究其應用。

並列摘要


The 1,8 - Naphthalimide derivatives are widely used in the synthesis of anticancer drugs. The activity of these compounds embed in DNA has been tested and the results are very good. In recent years, many scientists have devoted themselves to the study of new synthetic methods of synthesizing of 1,8 - Naphthalimide derivatives. It has been found that these compounds embedded in breast cancer cells, colorectal cancer cells, and lung cancer cells very well. We designed two series of derivatives and hope to further study their applications in the future.

參考文獻


參考資料
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