This research intends to investigate the design wind loads of various rectangular cross-sectional high-rise buildings in terms of extreme pressure coefficients. By6 conducting wind pressure measurement tests in a well simulated turbulent boundary layer flow, 14 high-rise building models were individually processed a huge amount of records to formulate each extreme value distribution for each pressure tap over the surface. A Reverse-Weibull function was adopted to fit the shape parameter of each distribution and the coefficient of variation was calculated to indicate the fluctuation level of extreme values. From the contours of both parameters of 14 building models, it was concluded that the range of fitted shape parameters is from 0.0 to 0.5 and the coefficient of variation followed the tendency of turbulence intensity. Moreover, the optimal design pressure coefficients were found based on iterative calculation of target non-exceedance probability of 0.001 for structural classification III and then compared with the Cook and Mayne coefficients. It was generally found in these 14 building models, the suggested 78% by the Cook and Mayne coefficient is more conservative than the optimal coefficients and a reasonable re-distributed design fractile map for design is strongly recommend.