The 1st Part : We used condensation reaction and reduction-oxidation reaction to synthesize the starting materials. Then we used Ullmann-type reaction to synthesize 6H-indolo[2,3-b] quinoline and its derivatives. We also changed the different functional groups to test the tolerance of the synthetic strategy. The 2nd Part : By using the final products we get form first part, we successfully develop a new total synthesis to get Apocynaceae alkaloid, Neocryptolepine, in four steps. It has a wide spectrum of application in pharmacology.