Glaucoma is the second blindness diseases other than cataracts. If the pathway of aqueous humor somehow is forced and blocked up, the intraocular pressure will rise over the bearable limits of optical inner structures that leads to the damage of optic nerve, visual field loss, and ultimately sight loss. The open angle glaucoma is indicated by defect of trabecular meshwork tissue which leads to intraocular pressure hypertension via aqueous obstruction. In this thesis, a simulation mechanism of angle-closured glaucoma is proposed. The process is associated with increased intraocular pressure resulting from malfunction of aqueous drainage structures and malformation of vitreous body. Hence it damages the surrounding structures including optic nerves.