Information systems have become indispensable tools for survival and value creating of organization, along with the advancement of information technology and the growth of Internet since 1990s. Since the focus of information systems is not only on technology, but also on the social perspective of behavior. As a result, whether academia or practices, information systems issues have always been paid close attention. However, few studies have conducted from the view of academia to understand the trend of information issues. Thus, the purpose of this research is to investigate the global developmental trends of information systems. This research used Content Analysis to study the international leading academic journals in the field of information systems. Descriptive statistics and difference tests are the data analysis methods used to understand the status, characteristics, and trends of IS research. The results show that information systems research is slow, stable and no regular rule of topic change. Different journal emphasizes on different subjects, but are mainly about enterprise management, control, and external view. “IS Effectiveness Measurement” and “User Appreciation” are two major academic subjects among them. Overall, this research, aiming at understanding important topic trends in information systems, will enable instructors and researchers of information systems to make a better choice in course content adjustment, research direction and publication.