An increasing number of studies have been focusing on the clinical significance of frailty in geriatric medicine, and being frail is associated with poor prognosis in the elderly. However, the importance of frailty is constantly under-recognized among patients with chronic kidney disease or end stage renal disease. Frailty is a status of accumulating health deficits during the aging process, resulting in the loss of ability to deal with physical or psychological stress. Screening for frailty is now a promising tool for prognosis prediction, which is an integral component in community-based palliative care for renal patients. However, traditional prognostic modeling is incomprehensive for patients or their family members. At this point, frailty or not, might then be an additional indicator for renal patients and the healthcare professionals to foretell the outcome. In the current review, based on the clinical experiences of the medical staff in the National Taiwan University Hospital Jinshan branch, we discuss in depth the utility of frailty status in assisting the promotion of community-based palliative care for renal patients.