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CC BY-NC 4.0 · Arch Plast Surg 2014; 41(01): 35-39
DOI: 10.5999/aps.2014.41.1.35
Original Article

Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue

Moon Kyun Cho
Department of Dermatology, Soonchunhyang University College of Medicine, Seoul, Korea
,
Je Min An
Department of Dermatology, Soonchunhyang University College of Medicine, Seoul, Korea
,
Chul Han Kim
Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine, Seoul, Korea
,
Sang Gue Kang
Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine, Seoul, Korea
› Author AffiliationsSupported by: Soonchunhyang University
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BackgroundAurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue.

Methods Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens.

Results Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining.

Conclusions Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.

Keywords

Skin - Diabetes mellitus

This work was supported by the Soonchunhyang University Research Fund.




Publication History

Received: 30 May 2013

Accepted: 02 September 2013

Article published online:
02 May 2022

© 2014. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)

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