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2016, vol. 5, br. 1, str. 39-52
Alginati i slični egzopolisaharidi u biomedicini i farmaciji - kontrolisano oslobađanje lekova
aUniverzitet u Nišu, Prirodno-matematički fakultet, Odsek Hemija, Srbija
bUniverzitet u Nišu, Tehnološki fakultet, Leskovac, Srbija

e-adresagoranchem_yu@yahoo.com
Projekat:
Biljni i sintetički bioaktivni proizvodi novije generacije (MPNTR - 34012)
Kombinatorne biblioteke heterogenih katalizatora, prirodnih proizvoda, modifikovanih prirodnih proizvoda i njihovih analoga: put ka novim biološki aktivnim agensima (MPNTR - 172061)

Sažetak
Zbog velike dostupnosti, biokompatibilnosti, biodegradabilnosti, hidrofilnosti, kao i tehnoloških karakteristika, polisaharidi se široko koriste kao prirodni netoksični polimeri u različitim granama industrije (hrana, kozmetika, tekstil, građevinarstvo). U novije vreme, neki egzopolisaharidi (dekstran, pululan) su dobili značajnu ulogu u farmaceutskoj industriji. Od posebne važnosti su alginati, koji imaju nezamenljivu ulogu u biomedicini, obzirom da se u formi hidrogela uspešno primenjuju za imobilizaciju širokog spektra enzima, terapeutika, biohemijskih agenasa, kao i raznih vrsta mikroorganizama i ćelija (biljnih, životinjskih ili ljudskih). Alginatne mikrosfere se koriste za kontrolisano oslobađanje biološki aktivnih molekula, a mikrokapsule kao nosači ćelija u inženjeringu tkiva. Posebne pogodnosti proizilaze iz jednostavnosti konfiguracije alginatnog hidrogela, uključujući i mogućnost kontrolisane proizvodnje mikročestica i nanočestica. Uzimajući u obzir veoma važnu ulogu alginata u biomedicini i farmaciji, u ovom radu je posebna pažnja posvećena pripremi i primeni alginatnih matrica, mikrosfera i mikrokapsula, oblika koji mogu imati značajnu i nezamenljivu primenu. U tom smislu, ovaj rad pruža pregled različitih mogućnosti upotrebe polisaharidnih matrica za biomolekule, polisaharida kao ekscipijenasa farmaceutskih proizvoda za oralnu ili lokalnu primenu, kao i pregled primera inovativnih aplikacija.
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O članku

jezik rada: engleski
vrsta rada: pregledni članak
DOI: 10.5937/savteh1601039M
objavljen u SCIndeksu: 15.07.2016.

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