Öz
Objective: Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. PD also involves nonmotor manifestations such as autonomic failure, cognitive disorders, and sleep disorders. These clinical characteristics are not identical in severity, frequency, and onset time in all PD patients. We assessed whether there is a negative effect on cognition of clinical autonomic
dysfunction in PD patients.
Methods: This prospective
study includes 37 PD patients with autonomic failure. From each patient, a questionnaire (SCOPA-AUT) including
symptoms
associated with clinical
autonomic
dysfunction such as
constipation, urinary
incontinence, orthostatic
hypotension, and hyperhydrosis was obtained and the patient’s clinical condition was rated
on the Hoehn and Yahr (H-Y) scale in the ON-medication
state. The patients’ cognitive function was assessed by the Mini-Mental State Examination (MMSE), Blessed score, Frontal Assessment Battery (FAB), and Digid Span Test (DST)
(forward, reverse). Cognitive test scores were compared with SCOPA-OUT scores.
Results: Mean age was 66,5±11.2 years. There was no correlation between cognitive test scores and SCOPA
-OUT scores (p>0.05). However,
H-Y
scores were
negatively correlated
with the DSTf, DSTr, FAB,
and
MMSE scores
(p50.005, r:-0.451;
p50.025, r: -0.367; p50.040, r:
-0.340; p50.044, r5-0.333, respectively).
Conclusions: According to our results, clinical autonomic dysfunction did not seem to ha ve an effect on cognition. In addition, severity of cognitive dysfunction showed a strong negative correlation with the stage of disease.
Anahtar Kelimeler
Blessed score Clinical autonomic dysfunction Cognitive test Parkinson’s disease
Kaynakça
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Ayrıntılar
| Bölüm | Araştırma Yazıları |
|---|---|
| Yazarlar | |
| Yayımlanma Tarihi | 20 Eylül 2017 |
| Gönderilme Tarihi | 20 Eylül 2017 |
| Yayımlandığı Sayı | Yıl 2017 Cilt: 44 Sayı: 3 |