Crohn's disease susceptibility variants in Colombian tuberculosis patients
OBJECTIVE: To assess the association of genetic polymorphisms previously associated with Crohn's disease and PTB in a Colombian population of PTB patients and controls.
DESIGN: A case-control study was performed among 500 newly diagnosed PTB patients and 320 healthy control subjects. Thirty-one single nucleotide polymorphisms (SNPs) identified in a previous meta-analysis of genome-wide association studies of Crohn's disease were used for genotyping using MassARRAY technology.
RESULTS: In this study, we identified an association with borderline significance (P = 0.0009433 and P = 0.029 after multiple testing by Bonferroni's correction) of SNP rs10995271 with PTB. SNP rs10995271 is in linkage disequilibrium with SNPs belonging to the zinc finger protein (ZNF365) gene.
CONCLUSIONS: Our results suggest that human PTB shares a genetic basis with Crohn's disease, and that SNPs in the ZNF365 gene would have a role in the occurrence of chronic granulomatous inflammatory reaction in TB as well as Crohn's disease.
Keywords: C13Orf31; ZNF365; gene polymorphisms; tuberculosis
Document Type: Research Article
Affiliations: 1: Grupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia; Centro Colombiano de Investigación en Tuberculosis, Medellin, Colombia; Health Sciences Center, Louisiana Cancer Research Center, Louisiana State University, New Orleans, Louisiana, USA 2: Laboratory in Genetics and Genomic Medicine of Inflammation, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada; ECOGENE-21 Clinical Trial Center, Centre de Médecine Génique Communautaire de l'Université de Montréal, Centre Hospitalier Affilié Universitaire Régional de Chicoutimi, Chicoutimi, Québec, Canada 3: Grupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia; Centro Colombiano de Investigación en Tuberculosis, Medellin, Colombia 4: Laboratory in Genetics and Genomic Medicine of Inflammation, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada 5: Grupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia; Centro Colombiano de Investigación en Tuberculosis, Medellin, Colombia
Publication date: 01 January 2014
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