Multiple viral coinfections among HIV/AIDS patients in China

Na He; Li Chen; Haijiang Lin; Man Zhang; Jun Wei; Jianhua Yang; Jenna Gabrio; Baoling Rui; Zuo-Feng Zhang; Zhuohua Fu; Yingying Ding; Genming Zhao; Qingwu Jiang; Roger Detels

doi:10.5582/bst.2011.v5.1.1

Original Articles

Multiple viral coinfections among HIV/AIDS patients in China

Na He, Li Chen, Haijiang Lin, Man Zhang, Jun Wei, Jianhua Yang, Jenna Gabrio, Baoling Rui, Zuo-Feng Zhang, Zhuohua Fu, Yingying Ding, Genming Zhao, Qingwu Jiang, Roger Detels

Author information

Na He
Department of Epidemiology, School of Public Health, Fudan University; Key Laboratory of Public Health Safety of Ministry of Education
Li Chen
Department of Epidemiology, School of Public Health, Fudan University; Key Laboratory of Public Health Safety of Ministry of Education
Haijiang Lin
Department of Epidemiology, School of Public Health, Fudan University; Key Laboratory of Public Health Safety of Ministry of Education
Taizhou City Center for Disease Control and Prevention
Man Zhang
Urumqi City Center for Disease Control and Prevention
Jun Wei
Yuncheng Prefecture Center for Disease Control and Prevention
Jianhua Yang
Yingjiang County Center for Disease Control and Prevention
Jenna Gabrio
Department of International Health, School of Nursing and Health Sciences, Georgetown University
Baoling Rui
Urumqi City Center for Disease Control and Prevention
Zuo-Feng Zhang
Department of Epidemiology, School of Public Health, Fudan University; Key Laboratory of Public Health Safety of Ministry of Education
Department of Epidemiology, School of Public Health, University of California
Zhuohua Fu
Department of Epidemiology, School of Public Health, Fudan University; Key Laboratory of Public Health Safety of Ministry of Education
Yingying Ding
Department of Epidemiology, School of Public Health, Fudan University; Key Laboratory of Public Health Safety of Ministry of Education
Department of Epidemiology, School of Public Health, University of California
Genming Zhao
Department of Epidemiology, School of Public Health, Fudan University; Key Laboratory of Public Health Safety of Ministry of Education
Qingwu Jiang
Department of Epidemiology, School of Public Health, Fudan University; Key Laboratory of Public Health Safety of Ministry of Education
Roger Detels
Department of Epidemiology, School of Public Health, University of California

Keywords: Coinfection, HSV, EBV, HBV/HCV, HIV, Chinese

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2011 Volume 5 Issue 1 Pages 1-9

DOI https://doi.org/10.5582/bst.2011.v5.1.1

Details

Abstract

A cross-sectional survey was conducted to determine seroprevalence and correlates of coinfections of hepatitis B virus (HBV), hepatitis C virus (HCV), Epstein-Bar virus (EBV), herpes simplex virus including type 1 (HSV-1) and type 2 (HSV-2) among human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients in China. A total of 1,110 HIV/AIDS patients from Shanxi (Central area, n = 287), Zhejiang (Eastern area, n = 163), Yunnan (Southwestern area, n = 300) and Xinjiang (Northwestern area, n = 360) provinces were analyzed. The overall seroprevalence was 6.3% for HBsAg, 59.0% for anti-HCV IgG, 96.6% for anti-EBV IgG, 91.5% for anti-HSV-1 IgG, and 34.1% for anti-HSV-2 IgG. Eleven (1.0%) HIV/AIDS patients were coinfected with all five viruses, 177 (15.9%) with four viruses, 611 (55.0%) with three viruses, 288 (25.9%) with two viruses, 23 (2.1%) with single virus, and 1 (0.1%) with none of the five viruses. Multiple logistic regression analyses indicated that neither HBV, nor EBV and HSV-1 coinfection was associated with sociodemographic characteristics and HIV transmission mode, but HCV coinfection was associated with geographic region, age, gender, ethnicity, marital status, and HIV transmission mode, whereas HSV-2 coinfection was associated with geographic region, ethnicity and HIV transmission mode. This study suggests that HIV/AIDS patients with different regional and sociodemographic backgrounds and HIV transmission mode in China have different profiles of viral coinfections and should be subject to differential considerations in related health care programs.

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