Ten 1,10-secoguaianolides were isolated from the flowers of Achillea millefolium. Their structures were determined on the basis of spectroscopic methods. Three of them (millifolides A-C) including two dimeric sesquiterpenoids exhibit new skeletons. Seco-tanapartholide A exhibited moderate cell growth inhibitory activity against the human cancer cell line MCF7WT (IC50 = 5.51 μm) in vitro.
Graphical Abstract
Millifolides A–C. New 1,10-Seco-guaianolides from the Flowers of Achillea millefolium
Keywords: Achillea millefolium; 1,10-Seco-guaianolides; Millifolides A to C; Structure Elucidation; Cell Growth Inhibition
Received: 2012-1-27
Published Online: 2014-6-2
Published in Print: 2012-5-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
