Relationship of the Polyunsaturated to Saturated Fatty Acid Ratio to Cardiovascular Risk Factors and Metabolic Syndrome in Japanese: the INTERLIPID Study

Zhao Guo; Katsuyuki Miura; Tanvir Chowdhury Turin; Atsushi Hozawa; Nagako Okuda; Tomonori Okamura; Shigeyuki Saitoh; Kiyomi Sakata; Hideaki Nakagawa; Akira Okayama; Katsushi Yoshita; Takashi Kadowaki; Sohel R Choudhury; Yasuyuki Nakamura; Beatriz L Rodriguez; David J Curb; Paul Elliott; Jeremiah Stamler; Hirotsugu Ueshima

doi:10.5551/jat.4135

Original Article

Relationship of the Polyunsaturated to Saturated Fatty Acid Ratio to Cardiovascular Risk Factors and Metabolic Syndrome in Japanese: the INTERLIPID Study

Zhao Guo, Katsuyuki Miura, Tanvir Chowdhury Turin, Atsushi Hozawa, Nagako Okuda, Tomonori Okamura, Shigeyuki Saitoh, Kiyomi Sakata, Hideaki Nakagawa, Akira Okayama, Katsushi Yoshita, Takashi Kadowaki, Sohel R Choudhury, Yasuyuki Nakamura, Beatriz L Rodriguez, David J Curb, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima

Author information

Zhao Guo
Department of Health Science, Shiga University of Medical Science.
Katsuyuki Miura
Department of Health Science, Shiga University of Medical Science.
Tanvir Chowdhury Turin
Department of Health Science, Shiga University of Medical Science.
Atsushi Hozawa
Department of Public Health and Forensic Medicine, Tohoku University School of Medicine.
Nagako Okuda
Department of Health Science, Shiga University of Medical Science.
Tomonori Okamura
National Cardiovascular Center.
Shigeyuki Saitoh
2nd Department of Internal Medicine, Sapporo Medical University.
Kiyomi Sakata
Department of Hygiene and Preventive Medicine, Iwate Medical University School of Medicine.
Hideaki Nakagawa
Department of Epidemiology and Public Health, Kanazawa Medical Univerisy.
Akira Okayama
The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association.
Katsushi Yoshita
National Institute of Health and Nutrition.
Takashi Kadowaki
Department of Health Science, Shiga University of Medical Science.
Sohel R Choudhury
Department of Noncommunicable Diseases and Mental Health, WHO
Yasuyuki Nakamura
Kyoto Women's University.
Beatriz L Rodriguez
John A. Burns School of Medicine, University of Hawaii.
David J Curb
John A. Burns School of Medicine, University of Hawaii.
Paul Elliott
Department of Epidemiology and Public Health, Faculty of Medicine, St Mary's Campus, Imperial College.
Jeremiah Stamler
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University
Hirotsugu Ueshima
Department of Health Science, Shiga University of Medical Science.

Keywords: Polyunsaturated fatty acid, Saturated fatty acid, P/S ratio, Metabolic syndrome, Japanese

JOURNAL OPEN ACCESS

2010 Volume 17 Issue 8 Pages 777-784

DOI https://doi.org/10.5551/jat.4135

View "Advance Publication" version (March 30, 2010).

Details

Abstract

Aim: There have been few studies on the relationships of the dietary polyunsaturated to saturated fatty acid ratio (P/S) to cardiovascular risk factors and metabolic syndrome. We hypothesized that there would be favorable relationships.
Methods: Metabolic cardiovascular risk factors from dietary nutrient intake were investigated in 1,004 men and women aged 40-59 years from 4 population samples of Japanese. Multiple linear regression analysis was used to examine the relationship of the dietary P/S ratio to the following risk factors: hemoglobin A1c, blood pressure, serum triglycerides, LDL and total cholesterol, and HDL-cholesterol. Adjusted odds ratio of having metabolic syndrome was also calculated.
Results: The dietary P/S ratio was significantly and inversely related to serum total and LDL cholesterol with control for possible confounding variables. We did not find any significant relationship between the P/S ratio and single metabolic risk factors or the prevalence of metabolic syndrome.
Conclusions: Managing the P/S ratio is important to control serum LDL-cholesterol; however, increasing the P/S ratio may not improve metabolic risk factors. Other countermeasures, such as weight control, greater physical activity, and smoking cessation should be recommended to prevent and control metabolic syndrome.

Corresponding author

Register with J-STAGE for free!