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    Korean J Androl. 2011 Aug;29(2):161-167. Korean.
    Published online Aug 31, 2011.
    https://doi.org/10.5534/kja.2011.29.2.161
    Copyright © Korean Society for Sexual Medicine and Andrology
    Original Article

    The Effect of 5-alpha Reductase Inhibitors on the Efficacy of Photoselective Vaporization of the Prostate with 120 W GreenLight HPS Laser

    Hyun Jun Park, Hyun Woo Kim, Tae Nam Kim and Nam Cheol Park
      • Department of Urology, Pusan National University School of Medicine, Busan, Korea.
    • Corresponding author (Email: pnc@pusan.ac.kr )
    Received April 04, 2011; Revised July 19, 2011; Accepted July 21, 2011.

    Abstract

    Purpose

    To evaluate the effect of preoperative 5-alpha reductase inhibitor (ARI) administration on the operative results of photoselective vaporization of prostate with 120W GreenLight HPS laser.

    Materials and Methods

    Data were collected from 98 benign prostatic hyperplasia (BPH) patients who underwent transurethral electrovaporization of prostate by 120W Greenlight HPS laser between Jan. 2010 and Dec. 2010. We compared the time of operation, the energy required in lasering, postoperative maximum uroflow velocity, change in residual urine volume and complications between 5-ARI administrating group and control group.

    Results

    56 patients administrated 5-ARI at least 3 months before surgery. 30 and 26 patients administrated finasteride and dutasteride, respectively. Mean follow up period was 4.1±1.8 months. Mean age of the subjects and mean prostate volume were not different. Mean change of postoperative hemoglobin, lasing time and energy required in lasering were greater in 5-ARI administrating group. There were 3 and 1 cases of acute urinary retension in 5-ARI administrating group and control group, respectively.

    Conclusions

    The mean change of hemoglobin and mean energy required in lasering were greater and mean lasing time was longer in the patients who administrated 5-ARI before photoselective vaporization of prostate by 120W Greenlight HPS laser. Further investigation and extensive study will be needed to confirm these results.

    Keywords
    Prostate hyperplasia; 5-alpha reductase inhibitors; Transurethral vaporesection of prostate

    Tables

    Table 1
    Preoperative characteristics of the 98 patients

    Table 2
    Operative end point and postoperative outcomes of the 98 patients

    Table 3
    Comparison of preoperative characteristics between finasteride and dutasteride group

    Table 4
    Comparison of operative end point and postoperative outcomes between finasteride and dutasteride group

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    MeSH Terms
    5-alpha Reductase Inhibitors
    Azasteroids
    Dutasteride
    Finasteride
    Follow-Up Studies
    Hemoglobins
    Humans
    Oxidoreductases
    Prostate
    Prostatic Hyperplasia
    Transurethral Resection of Prostate
    Volatilization
    Metrics
    Share
    Tables
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