Role of Melia azedarach leaf extract in Paracetamol Induced Hepatic damage in rats

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Abstract

The hepataprotective activity of the methanolic leaf extract of Melia azedarach was investigated against paracetamol induced hepatic damage in rats. Over dosing of paracetamol to rats is reported to decrease the activity of antioxidative enzymes (GPx, GST, SOD and CAT ) in liver and increase the serum enzymes (SGOT , SGPT and Alkaline phosphate), bilirubin and decrease the total proteins content. Melia azedarach leaf extract maintained the activity of antioxidant enzymes and as well as serum enzymes to the normal level. Thus the present study ascertains that the leaf extract of Melia azedarach possesses significant hepatoprotective activity.

References (29)

  • CB Wandscheer et al.

    (Larvicidal action of ethanolic extracts from fruits endocarps of melia azedarach and Azadirachta indica against the dengue mosquito

    Aedes Aegypti. Toxicon

    (2004 Dec. 15)
  • OH Lowry et al.

    Protein measurement with the folin-phenol reagent

    J Biol Chem

    (1951)
  • L Simonsen et al.

    Unsafe infections in the developing world and transmission of bloodborne pathogens

    Bull World Health Organ

    (1999)
  • M Gupta et al.

    Antioxidant and protective effects of Ervatamia coronaria Stapf., leaves against carbon tetrachloride - induced liver injury

    European Bull Drug Res

    (2004)
  • M Gupta et al.

    Antioxidant and hepatoprotective effects of Bauhinia racemosa against paracetamol and carbon tetrachloride - induced liver damage in rats

    Iranian J Pharmacol Therapeutics

    (2004)
  • V Kukongviriyapan et al.

    Hepatoprotective and antioxidant activities of Tetracera loureiri

    Phytother Res

    (2003)
  • S Sannigrahi et al.

    Hepatoprotective potential of methanol extract of Clerodendrum infortunatum Linn. against CCl4 induced hepatotoxicity in rats

    Phcog Mag

    (2009)
  • RP Gutierrez et al.

    Antioxidant and hepatoprotective effects of the methanol extract of the leaves of Satureja macrostema

    Phcog Mag

    (2010)
  • NK Bairwa et al.

    Protective effect of stem bark of Ceiba pentandra linn. against paracetamol-induced hepatotoxicity in rats

    Phcog Res

    (2010)
  • H Lata et al.

    Role of free radicals in health and disease

    Ind J Physiol & Allied Sci.

    (2003)
  • UK Mazumder et al.

    Antihyperglycemic effect and antioxidant potential of Phyllanthus niruri (Euphorbiaceae) in streptozotocin induced diabetic rats

    European Bull Drug Res

    (2005)
  • S Bhawna et al.

    Hepatoprotective activity of some indigenous plants

    Int. J. Pharm. Tech. Res

    (2009)
  • MT Olaleye et al.

    Alchornea cordifolia extract protects wistar albino rats against acetaminopheninduced liver damage

    Afr. J. Biotechnol

    (2006)
  • H.P. Rang, M.M. Dale, J.M. Ritter, P.K. Moore et al, Pharmacology fifth edition. Page no:...
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