Supporting data for "Trajectories, bifurcations and pseudotime in large clinical datasets: applications to myocardial infarction and diabetes data"
Dataset type: Metadata, Software
Data released on October 20, 2020
Golovenkin S; Bac J; Chervov A; Mirkes E; Orlova Y; Barillot E; Gorban A; Zinovyev A (2020): Supporting data for "Trajectories, bifurcations and pseudotime in large clinical datasets: applications to myocardial infarction and diabetes data" GigaScience Database. https://doi.org/10.5524/100819
Large observational clinical datasets become increasingly available for mining associations between various disease traits and administered therapy. These datasets can be considered as representations of the landscape of all possible disease conditions, in which a concrete pathology develops through a number of stereotypical routes, characterized by `points of no return' and `final states' (such as lethal or recovery states). Extracting this information directly from the data remains challenging, especially in the case of synchronic (with a short-term follow up) observations. Here we suggest a semi-supervised methodology for the analysis of large clinical datasets, characterized by mixed data types and missing values, through modeling the geometrical data structure as a bouquet of bifurcating clinical trajectories. The methodology is based on application of elastic principal graphs which can address simultaneously the tasks of dimensionality reduction, data visualization, clustering, feature selection and quantifying the geodesic distances (pseudotime) in partially ordered sequences of observations. The methodology allows positioning a patient on a particular clinical trajectory (pathological scenario) and characterizing the degree of progression along it with a qualitative estimate of the uncertainty of the prognosis. Overall, our pseudotime quantification-based approach gives a possibility to apply the methods developed for dynamical disease phenotyping and illness trajectory analysis (diachronic data analysis) to synchronic observational data. We developed a tool ClinTrajan for clinical trajectory analysis implemented in Python programming language. We test the methodology in two large publicly available datasets: myocardial infarction complications and readmission of diabetic patients data.
Keywords:
Additional details
Read the peer-reviewed publication(s):
- Golovenkin, S. E., Bac, J., Chervov, A., Mirkes, E. M., Orlova, Y. V., Barillot, E., Gorban, A. N., & Zinovyev, A. (2020). Trajectories, bifurcations, and pseudo-time in large clinical datasets: applications to myocardial infarction and diabetes data. GigaScience, 9(11). https://doi.org/10.1093/gigascience/giaa128 (PubMed:33241287)
Additional information:
https://scicrunch.org/resolver/RRID:SCR_019018
https://doi.org/10.25392/leicester.data.12045261.v3
https://www.kaggle.com/brandao/diabetes
https://archive.ics.uci.edu/ml/datasets/diabetes+130-us+hospitals+for+years+1999-2008
Github links:
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Table SettingsFile Name | Description | Sample ID | Data Type | File Format | Size | Release Date | File Attributes | Download |
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Readme | TEXT | 3.45 kB | 2020-10-18 | MD5 checksum: 3e2f413b221827cfb2676b0c060db3c5 |
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Archival copy of the GitHub repository https://github.com/sysbio-curie/ClinTrajan/releases/tag/v1.0 downloaded 20-Oct-2020. ClinTrajan - Methodology and software for quantifying pseudotemporal trajectories in clinical datasets. This project is licensed under the LGPL license. Please refer to the GitHub repo for most recent updates. | GitHub archive | zip | 24.34 MB | 2020-10-18 | license: LGPL MD5 checksum: 8bfb8149b9bc6172723f352d135aefbf |
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Archival copy of the GitHub repository https://github.com/sysbio-curie/scikit-dimension/releases/tag/v0.1 downloaded 20-Oct-2020. scikit-dimension. This project is licensed under the BSD 3-Clause license. Please refer to the GitHub repo for most recent updates. | GitHub archive | zip | 309.94 kB | 2020-10-18 | license: BSD 3-Clause MD5 checksum: 46e974acea16c2ce8a4b861908e2a7dc |
Funding body | Awardee | Award ID | Comments |
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Ministry of Science and Higher Education of the Russian Federation | A Gorban | 14.Y26.31.0022 | |
Agence Nationale de la Recherche | A Zinovyev | ANR-19-P3IA-0001 | PRAIRIE 3IA |
European Union | A Zinovyev | 826121 | Horizon 2020 Program iPC project |
Date | Action |
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October 20, 2020 | Dataset publish |
October 26, 2020 | Manuscript Link added : 10.1093/gigascience/giaa128 |
October 7, 2022 | Manuscript Link updated : 10.1093/gigascience/giaa128 |