This brief overview highlights the global crisis of perinatal psychiatric illness (PPI). PPI is a major contributor to many adverse pregnancy, childbirth, and childhood development outcomes. It contributes to billions of dollars in spending worldwide each year and has a significant impact on the individual, their family, and their community. It is also highly preventable. Current recommendations for intervention and management of PPI are limited and vary considerably from country to country. Furthermore, there are several significant challenges asso-ciated with implementation of these recommendations. These challenges are magnified in number and consequence among women of color and/or minority populations, who experience persistent and negative health disparities during pregnancy and the postpartum period. This paper aims to provide a broad overview of the current state of recommendations and implementation challenges for PPI and layout a framework for overcoming these challenges. An equity-informed model of care that provides universal intervention for pregnant women may be one solution to address the preventable consequences of PPI on child and maternal health. Uniquely, this model emphasizes the importance of managing and eliminating known barriers to traditional health care models. Culturally and contextually specific challenges must be overcome to fully realize the impact of improved management of PPI.

Rates of maternal morbidity and mortality are a global health crisis. In 2017, 295000 women worldwide perished due to maternal causes[1]. Global maternal mortality rates are estimated at 211 maternal deaths per 100000 live births. The lifetime risk of maternal mortality for a 15-year-old girl is estimated at 1 in 190[1]. Mortality rates are more than 40 times higher in underdeveloped countries compared to developed geographic areas such as Europe and Australia[1]. There are major differences in rates of maternal mortality and morbidity. Differences can be seen between countries, with sub-Saharan Africa and Southern Asia accounting for approximately 86% of all estimated global maternal deaths in 2017[1]. Differences based on minority status can also be seen within countries. In the United States, Black women are 2.5 times more likely to die in childbirth than White women[2]. In the United Kingdom, Black and Asian women are more likely to die of maternal-related causes than White women[3]. Ethnic minorities (e.g., non-Han women) in China have higher maternal mortality rates than non-minority populations (e.g., Han women[4]). In Brazil, non-white women are 3.5 times more likely to die from obstetric deaths than White women[5]. In Australia, Indigenous women have a maternal mortality rate 4.6 times higher than non-Indigenous women[6]. These trends are consistent worldwide.

Maternal Mortality Review Committees have determined that 11% of pregnancy-related deaths are due to perinatal psychiatric illness (PPI), and these deaths are 100% preventable[7]. PPI is the most common morbidity in pregnancy and the leading cause of mortality during the perinatal period in developed nations[8]. PPI is a significant contributor to poor outcomes throughout pregnancy, childbirth, and postpartum. Rates of PPI in high-income countries range from 7%-15%, while the prevalence ranges from 19%-25% in low- and middle-income countries[9]. Women of color are especially at risk for PPI. In the United States, Black, Asian/Pacific Islander and Hispanic/Latinx women report experiencing PPI at 2-5 times the rates of White women[10,11]. In the United Kingdom, non-White (especially Asian) women experience PPI at higher rates than White women[12]. In Norway, the prevalence of PPI in women of underrepresented ethnicities was almost 3 times that of Western Europeans[13]. Research on racial disparities is limited. Many studies combine all racial and/or ethnic minorities together, which disregards important differences between races and cultures.

PPI refers to any psychiatric illness experienced from the beginning of pregnancy up to 1 year postpartum. A landmark study of 10000 mothers found that of women who screened positive for depression, 27% reported being depressed before pregnancy and 33% reported that their depression began during pregnancy[14]. Though many primarily think of postpartum depression when referring to PPI, there are several psychiatric illnesses that are prevalent and related to negative outcomes during the perinatal period. Perinatal depression is indeed common, occurring in around 25% of women[15]. It refers to the occurrence of a major depressive episode in the perinatal period, marked by low mood, low energy, sleep problems (apart from caring for the infant), and sometimes suicidal thoughts. This is differentiated from what has been called the “baby blues” or the “maternity blues”, which refers to a transient affective disturbance that usually peaks within 5 d after childbirth[16]. PPI also refers to psychiatric symptoms beyond depression. Perinatal anxiety presents with symptoms such as excessive and uncontrollable worries about the baby and motherhood, fear of childbirth, and intrusive thoughts of the baby being harmed or dying[17]. It may occur at higher rates than perinatal depression[18]. Perinatal obsessive-compulsive disorder is more common than obsessive-compulsive disorder in the general population and is marked by obsessions and compulsions related to the baby[19]. Obsessions are generally related to fears of contamination and harming the baby and compulsions may include avoidance of child-rearing tasks and mental rituals[19]. Perinatal post-traumatic stress disorder (PTSD) refers either to a recurrence of PTSD brought on by major life changes during pregnancy and postpartum or to new onset PTSD secondary to traumas experienced during pregnancy or childbirth. Symptoms include nightmares, avoidance of stimuli associated with the trauma, and negative appraisals of self and others related to the trauma[20]. Finally, perinatal psychosis, though relatively rare, is an emergent situation. It typically occurs within 2-3 d of childbirth, though emerging evidence suggests that some women may even experience it prenatally. It is most common in women with a history of bipolar disorder or with a first-degree relative with schizophrenia or bipolar disorder[21].

PPI is associated with a range of negative outcomes. Women experiencing PPI tend to initiate prenatal care later and miss more appointments. Both factors are highly associated with poor childbirth outcomes[22-24] and are targets for appropriate intervention like psychoeducation and enhanced awareness of PPI. PPI is also associated with pregnancy and delivery complications (such as high blood pressure, gestational diabetes premature labor, low infant APGAR score, low birth weight[25]). Specific findings stratifying risk by ethnicity and race are limited. One United States study found that non-Hispanic Black and Asian women have higher levels of risk for preterm birth while depressed than White women, and Hispanic women were not at higher risk for preterm birth when depressed[26].

Women with PPI and their babies also experience postpartum comorbidities associated with psychiatric illness. Women with PPI have more trouble bonding with their baby, and mental health concerns can be seen 4-5 years postpartum in 30%-40% of women[22,27,28]. The children of women with untreated psychiatric distress go on to have higher rates of psychiatric illness, behavioral problems, and academic difficulties[29]. To illustrate, a French study showed increased externalizing and internalizing behavior and poor motor and regulation skills in 1-year-old children of mother with perinatal depression[30]. These findings were replicated in a large (n = 2698) study out of the Netherlands examining internalizing behavior in 3-year-old children of women with perinatal anxiety and depression[31]. Studies of teenagers (aged 16 to 17-years-old) in Finland and the United Kingdom demonstrated increased risk for depression and low social competence when their mother had experienced perinatal depression[32,33].

Risk factors for PPI are myriad and many are quite common. Individual risk factors include unwanted pregnancy (50% of pregnancies), primiparity (i.e., first pregnancy), and fertility difficulties[34]. Social determinants of health related to PPI include childhood maltreatment, especially childhood sexual violence, which affects up to 25% of girls from low-income and middle-income countries[9]. Other social determinants that increase risk for PPI and are disproportionately experienced by women of color and underrepresented ethnicities are poverty, poor nutrition, lower levels of educational attainment, low social support, gender discrimination and gender-based violence, and previous mental health conditions[9,34,35]. Again, studies stratifying risk for PPI by race and ethnicity are extremely limited, though there is evidence for the deleterious impact of immigration and race-based discrimination on mental health (i.e., increased risk for PPI) in the perinatal period[36]. Adversity more commonly observed in underrepresented populations, such as intimate partner violence, childhood trauma and military deployment, is also associated with greater risk for mental health outcomes[36].

Untreated PPI can have devastating consequences for mothers, their partners, their children, their workplaces, and their communities. At the population level, PPI is associated with increased healthcare costs, inappropriate use of healthcare (i.e., excess- and under-utilization as well as increased use of emergent care), child abuse, family dysfunction, and, at worst, suicide, homicide, and infanticide[22,37]. At the individual level, PPI impacts the mother’s health, attachment with their child, the infant’s health, and can lead to suicide or homicide[38,39]. At an economic level, the cost of PPI is significant. Though research on exact costs worldwide are limited, studies out of Canada and South Africa suggest that women with PPI utilize services costing roughly 2 times those of women without PPI[40,41]. In the United States, PPI costs an estimated $14 billion per year, including cost estimates of loss of productivity and direct healthcare[42]. Even when strictly examining medical costs in the United States, PPI costs 5 times as much as other pregnancy concerns like gestational diabetes or postpartum hemorrhage[43].

Given the regular touchpoints between pregnant women and providers during the prenatal period and the onset of many psychiatric concerns during the prenatal period, pregnancy offers an optimal time for early detection and intervention for perinatal mental health problems[44]. The American College of Obstetricians and Gynecologists recommends 13 care appointments during the prenatal period[45]. Evidence suggests that prenatal mental health interventions are effective at improving health outcomes and preventing psychiatric distress, but PPI is significantly under-identified and largely under-treated[46].

In response to mounting concerns related to PPI and its impact on women and communities, initiatives to improve care have focused on universal screening. In the United States, the following organizations all recommend at least one screening for perinatal depression with a validated measure during the perinatal period: American College of Obstetricians and Gynecologists, American Academy of Pediatrics, United States Preventive Services Task Force (USPSTF), Centers for Medicare and Medicare Services, Council on Patient Safety in Women’s Health Care[47-50]. The USPSTF specifies that screenings should only occur when there are significant resources for effective treatment and follow-up[51]. In the United Kingdom, universal screening is recommended by the National Institute for Health and Care Excellence, though again, only when there are resources available for treatment and follow-up[52]. This is consistent with guidelines suggested by the World Health Organization in 2022[34] which suggested a stepped-care approach to the integration of perinatal mental health services into maternal health care. In Canada, universal screening is not recommended by the Canadian Task Force on Preventive Healthcare due to paucity of evidence for its benefits[53].

Though there are some benefits to universal screening, including the low cost and low provider burden of having patients complete the forms, at least four major challenges have arisen with the current recommendations for universal screening in the perinatal period. Each challenge impacts all pregnant women, and each is also uniquely impactful in the outcomes of women of color.

The above-described challenges inherent to universal screening reflect profound health inequities for pregnant women and especially pregnant women of color. Current standards of care (e.g., universal screening and referral) were developed using the traditional medical framework, within which health inequities are increasing worldwide[79-81]. Even countries that provide universal health services to their citizens demonstrate major inequities based on race and ethnicity in their perinatal care. For example, in a large study in the United Kingdom examining over 600000 women who gave birth, Black African, Asian, and White non-British women had significantly lower access to outpatient mental health services than White British women[82]. Moving the needle on PPI and thus maternal mortality and morbidity will require approaches that are fundamentally aware of and responsive to health inequities in a way that traditional healthcare is not.

Equity-oriented care is positioned as an alternative to traditional care. It has been previously defined as “an approach that aims to reduce the effects of structural inequities, etc.; the impact of multiple and intersecting forms of racism, discrimination, and stigma (e.g., related to mental illness, chronic illnesses, non-conforming gender and sexual identities, etc.) on people’s access to services and their experiences of care; and the frequent mismatches between dominant approaches to care, etc., and the needs of people who are most affected by health and social inequities”[83]. An equity-oriented framework is trauma-informed (recognizing the higher rates of trauma and violence in communities of color), culturally safe (explicitly addressing power dynamics and historical mistrust in the medical system), and contextually tailored (highlighting skills and education relevant to the medical system and community)[84].

Therefore, a successful perinatal mental health intervention would deviate from the traditional model of screening to refer and would follow an equity-oriented model. This model would specifically address mental health stigmatization and work to reduce systemic racism in the medical context while addressing practical barriers to accessing care. A direct way to meet both needs is to move away from universal screening and toward universal intervention.

A universal intervention approach to psychiatric distress in pregnancy may eliminate known barriers to appropriate psychiatric management, thus improving trajectories for all pregnant women, and especially for women of color. Rather than losing women at every step of the screening-to-referral pipeline, provision of a universal intervention in the prenatal period ensures that evidence-based tools for prevention of PPI are delivered. Providing this intervention to all women is a novel approach to management of PPI.

Based on the accumulation of evidence regarding the most impactful interventions in the perinatal period, equity-oriented prenatal universal intervention should be trauma-informed[85] and limited to one 45-min session. This model is consistent with research suggesting that even one childbirth educational session is effective for improving outcomes and that requiring more sessions creates a barrier to psychiatric care[86,87]. It should be delivered in the prenatal period as either an adjunct to a standing prenatal appointment or as a separate appointment. It can be delivered by a mental health professional (e.g., contracted, embedded, or other) or potentially by a trained OB/GYN provider (e.g., nurse, MA, or other). Based on previous research regarding barriers to effective care as well as what is most helpful for women during the prenatal period, the universal intervention should include the following components: (1) Brief education about pregnancy and the childbirth process; (2) brief discussion of perinatal psychiatric issues in plain language; (3) discussion of trust and potential discomfort with providers; (4) explanation of skills for maximizing healthcare appointments; and (5) list of free and low cost resources available throughout pregnancy and after childbirth. Components 1-4 could be created and disbursed as relevant for all pregnant women while component 5 needs to be individualized to the clinic based on location and institutional/community resources.

This model is not without its challenges. Systems-level barriers continue to exist, whether healthcare is privatized or nationalized. In low-, middle-, and high-income countries, challenges include low levels of funding afforded to mental health services, inequalities in levels of access to mental health care, and shortages of mental health providers[94,95]. Decisions will need to be made in clinic as to whether the intervention should be delivered by an embedded mental health professional (MHP) or by an OB/GYN provider. Benefits of delivery by an MHP are need for limited training, ability to provide ongoing care in clinic, and reduced burden on an already overburdened OB/GYN staff. Benefits of delivery by an OB/GYN provider are the low resources needed for implementation and reduction in the likelihood that the provider will divert responsibility for mental health management fully to the MHP, a frequent occurrence when MHPs are embedded in primary care[66]. Finally, this model does not address the major shortage of psychiatrists and mental health practitioners, both of whom are necessary when ongoing care is needed for more serious PPI management.

As discussed above, universal intervention may address many of the concerns with universal screening. In summary, Table 1 discusses the advantages and disadvantages of universal screening (current state in many countries) and universal intervention (proposed model).

The application of a universal intervention model may de-stigmatize psychiatric care and address many of the barriers that continue to contribute to health disparities for women and especially women of color. Delivering a universal intervention to all patients, regardless of psychiatric distress within the context of prenatal care may improve individual and community outcomes for women by reducing stigma, increasing preparation, providing a connection to a psychiatric professional and improving mental health literacy. For women with psychiatric distress, a universal intervention may also provide a basic stress inoculation for pregnancy process, individualized referral to services if needed, and updated resources. If successful on a large scale, this intervention could contribute to changes in major international guidelines regarding the appropriate course of prenatal care.