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Clinical and biochemical characteristics of Sjögren’s syndrome and its differences from keratoconjunctivitis sicca

Year 2021, Volume: 34 Issue: 2, 208 - 214, 31.05.2021

Ismail Taskıran Umut Kalyoncu Sedat Kıraz

https://doi.org/10.5472/marumj.944279

Abstract

Objective: In this study we aimed to compare the clinical and biochemical characteristics of primary Sjögren’s syndrome patients with
that of keratoconjunctivitis sicca, secondary Sjögren syndrome and undifferentiated disease.
Patients and Methods: Patients with Sjögren’s syndrome and keratoconjunctivitis sicca who applied between August 2009 and January
2010 were included in this study. Demographic data, laboratory characteristics, Schirmer’s test and salivary gland biopsies of the
patients were recorded.
Results: Average diagnosis age for 87 primary Sjögren’s syndrome, 25 secondary Sjögren’s syndrome, 27 keratoconjunctivitis sicca and
44 undifferentiated group patients were 45±13, 43±14, 44±11 ve 45±11 years (p>0.05), accordingly. Critical and severe mouth dryness
rate was 45% in primary Sjögren’s syndrome group and 7% in keratoconjunctivitis sicca group, critical and severe eye dryness was 43%
in primary Sjögren’s syndrome group and 78% in keratoconjunctivitis sicca group (p<0.001). Grade 3≥ positivity in salivary gland
biopsy was found as 71.2% in primary Sjögren’s syndrome group and 27.2% in the undifferentiated group (p<0.001).
Conclusions: More dense lymphocyte infiltration was detected in primary Sjögren’s syndrome in salivary gland biopsies. As 27.2% of
undifferentiated group patients had positive salivary gland biopsies, they might need follow-ups in terms of having increased risk of
developing primary Sjögren’s syndrome.

Keywords

Keratoconjuctivitis sicca Schirmer’s test Sjögren’s syndrome

References

  • Jonsson R, Bowman SJ, Gordon TP. Sjögren’s syndrome. In: Koopman WJ, ed. Arthritis and Allied Conditions. Philadelphia: Lippincott Williams and Wilkins, 2005: 1681- 705.
  • Delaleu N, Jonsson R, Koller MM. Sjogren’s syndrome. Eur J Oral Sci 2005;113:101-13.doi:10.1111/j.1600- 0722.2004.00183.x
  • Strickland RW, Tesar JT, Berne BH, Hobbs BR, Lewis DM, Welton RC. The frequency of sicca syndrome in an elderly female population. J Rheumatol 1987;14:766-71
  • Chisholm DM, Mason DK. Labial salivary gland biopsy in Sjögren’s disease. J Clin Pathol 1968;21:656-60.
  • Stevens S. Schirmer’s test. Community Eye Health 2011;24:45.
  • Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. Classification criteria for Sjogren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61:554-8.doi:10.1136/ard.61.6.554
  • Strombeck B, Ekdahl C, Manthorpe R, Wikstrom I, Jacobsson L. Health-related quality of life in primary Sjogren’s syndrome, rheumatoid arthritis and fibromyalgia compared to normal population data using SF-36. Scand J Rheumatol 2000;29:20-8. doi:10.1080/030.097.400750001761
  • Carsons SE, Vivino FB, Parke A, et al. Treatment guidelines for rheumatologic manifestations of Sjögren’s syndrome: Use of biologic agents, management of fatigue, and inflammatory musculoskeletal pain. Arthritis Care Res 2017;69:517-27. doi. org/10.1002/acr.22968
  • Diaz-Lopez C, Geli C, Corominas H, Malat N, Diaz-Torner C, Llobet JM, et al. Are there clinical or serological differences between male and female patients with primary Sjogren’s syndrome? J Rheumatol 2004;31:1352-5
  • Gaches F, Delaire L, Nadalon S, Loustaud-Ratti V, Vidal E. [Frequency of autoimmune diseases in 218 patients with autoimmune thyroid pathologies]. Rev Med Interne 1998;19:173-9.doi:10.1016/s0248-8663(97)80716-3
  • Anaya JM, Jimenez PR, Rodriguez Y, et al. Sjögren’s syndrome and autoimmune thyroid disease: Two sides of the same coin. Clin Rev Allergy Immunol 2019;56:362-74. doi: 10.1007/ s12016.018.8709-9.
  • Garcia-Carrasco M, Siso A, Ramos-Casals M, Rosas J, de la Red G, Gil V, et al. Raynaud’s phenomenon in primary Sjogren’s syndrome. Prevalence and clinical characteristics in a series of 320 patients. J Rheumatol 2002;29:726-30
  • Schmidt KG, Ulmer HE, Silverman NH, Kleinman CS, Copel JA. Perinatal outcome of fetal complete atrioventricular block: a multicenter experience. J Am Coll Cardiol 1991;17:1360-6. doi:10.1016/s0735-1097(10)80148-2
  • Gupta S, Gupta N. Sjögren syndrome and pregnancy: A litearature review. Perm J 2017;21:16-047. doi: 10.7812/ TPP/16-047.
  • Zhang W, Feng S, Yan S, Zhao Y, Li M, Sun J, et al. Incidence of malignancy in primary Sjogren’s syndrome in a Chinese cohort. Rheumatology (Oxford) 2010;49:571-7.doi:10.1093/ rheumatology/kep404
  • Fragkioudaki S, Mavragani CP, Moutsopoulos HM. Predicting the risk for lymphoma development in Sjogren syndrome: An easy tool for clinical use. Medicine (Baltimore) 2016;95:e3766. doi:10.1097/MD.000.000.0000003766

Year 2021, Volume: 34 Issue: 2, 208 - 214, 31.05.2021

Ismail Taskıran Umut Kalyoncu Sedat Kıraz

https://doi.org/10.5472/marumj.944279

Abstract

References

  • Jonsson R, Bowman SJ, Gordon TP. Sjögren’s syndrome. In: Koopman WJ, ed. Arthritis and Allied Conditions. Philadelphia: Lippincott Williams and Wilkins, 2005: 1681- 705.
  • Delaleu N, Jonsson R, Koller MM. Sjogren’s syndrome. Eur J Oral Sci 2005;113:101-13.doi:10.1111/j.1600- 0722.2004.00183.x
  • Strickland RW, Tesar JT, Berne BH, Hobbs BR, Lewis DM, Welton RC. The frequency of sicca syndrome in an elderly female population. J Rheumatol 1987;14:766-71
  • Chisholm DM, Mason DK. Labial salivary gland biopsy in Sjögren’s disease. J Clin Pathol 1968;21:656-60.
  • Stevens S. Schirmer’s test. Community Eye Health 2011;24:45.
  • Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. Classification criteria for Sjogren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61:554-8.doi:10.1136/ard.61.6.554
  • Strombeck B, Ekdahl C, Manthorpe R, Wikstrom I, Jacobsson L. Health-related quality of life in primary Sjogren’s syndrome, rheumatoid arthritis and fibromyalgia compared to normal population data using SF-36. Scand J Rheumatol 2000;29:20-8. doi:10.1080/030.097.400750001761
  • Carsons SE, Vivino FB, Parke A, et al. Treatment guidelines for rheumatologic manifestations of Sjögren’s syndrome: Use of biologic agents, management of fatigue, and inflammatory musculoskeletal pain. Arthritis Care Res 2017;69:517-27. doi. org/10.1002/acr.22968
  • Diaz-Lopez C, Geli C, Corominas H, Malat N, Diaz-Torner C, Llobet JM, et al. Are there clinical or serological differences between male and female patients with primary Sjogren’s syndrome? J Rheumatol 2004;31:1352-5
  • Gaches F, Delaire L, Nadalon S, Loustaud-Ratti V, Vidal E. [Frequency of autoimmune diseases in 218 patients with autoimmune thyroid pathologies]. Rev Med Interne 1998;19:173-9.doi:10.1016/s0248-8663(97)80716-3
  • Anaya JM, Jimenez PR, Rodriguez Y, et al. Sjögren’s syndrome and autoimmune thyroid disease: Two sides of the same coin. Clin Rev Allergy Immunol 2019;56:362-74. doi: 10.1007/ s12016.018.8709-9.
  • Garcia-Carrasco M, Siso A, Ramos-Casals M, Rosas J, de la Red G, Gil V, et al. Raynaud’s phenomenon in primary Sjogren’s syndrome. Prevalence and clinical characteristics in a series of 320 patients. J Rheumatol 2002;29:726-30
  • Schmidt KG, Ulmer HE, Silverman NH, Kleinman CS, Copel JA. Perinatal outcome of fetal complete atrioventricular block: a multicenter experience. J Am Coll Cardiol 1991;17:1360-6. doi:10.1016/s0735-1097(10)80148-2
  • Gupta S, Gupta N. Sjögren syndrome and pregnancy: A litearature review. Perm J 2017;21:16-047. doi: 10.7812/ TPP/16-047.
  • Zhang W, Feng S, Yan S, Zhao Y, Li M, Sun J, et al. Incidence of malignancy in primary Sjogren’s syndrome in a Chinese cohort. Rheumatology (Oxford) 2010;49:571-7.doi:10.1093/ rheumatology/kep404
  • Fragkioudaki S, Mavragani CP, Moutsopoulos HM. Predicting the risk for lymphoma development in Sjogren syndrome: An easy tool for clinical use. Medicine (Baltimore) 2016;95:e3766. doi:10.1097/MD.000.000.0000003766
There are 16 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Articles
Authors

Ismail Taskıran This is me 0000-0001-5450-5133

Umut Kalyoncu This is me 0000-0001-7129-2109

Sedat Kıraz This is me 0000-0003-2802-6061

Publication Date May 31, 2021
Published in Issue Year 2021 Volume: 34 Issue: 2

Cite

APA Taskıran, I., Kalyoncu, U., & Kıraz, S. (2021). Clinical and biochemical characteristics of Sjögren’s syndrome and its differences from keratoconjunctivitis sicca. Marmara Medical Journal, 34(2), 208-214. https://doi.org/10.5472/marumj.944279
AMA Taskıran I, Kalyoncu U, Kıraz S. Clinical and biochemical characteristics of Sjögren’s syndrome and its differences from keratoconjunctivitis sicca. Marmara Med J. May 2021;34(2):208-214. doi:10.5472/marumj.944279
Chicago Taskıran, Ismail, Umut Kalyoncu, and Sedat Kıraz. “Clinical and Biochemical Characteristics of Sjögren’s Syndrome and Its Differences from Keratoconjunctivitis Sicca”. Marmara Medical Journal 34, no. 2 (May 2021): 208-14. https://doi.org/10.5472/marumj.944279.
EndNote Taskıran I, Kalyoncu U, Kıraz S (May 1, 2021) Clinical and biochemical characteristics of Sjögren’s syndrome and its differences from keratoconjunctivitis sicca. Marmara Medical Journal 34 2 208–214.
IEEE I. Taskıran, U. Kalyoncu, and S. Kıraz, “Clinical and biochemical characteristics of Sjögren’s syndrome and its differences from keratoconjunctivitis sicca”, Marmara Med J, vol. 34, no. 2, pp. 208–214, 2021, doi: 10.5472/marumj.944279.
ISNAD Taskıran, Ismail et al. “Clinical and Biochemical Characteristics of Sjögren’s Syndrome and Its Differences from Keratoconjunctivitis Sicca”. Marmara Medical Journal 34/2 (May 2021), 208-214. https://doi.org/10.5472/marumj.944279.
JAMA Taskıran I, Kalyoncu U, Kıraz S. Clinical and biochemical characteristics of Sjögren’s syndrome and its differences from keratoconjunctivitis sicca. Marmara Med J. 2021;34:208–214.
MLA Taskıran, Ismail et al. “Clinical and Biochemical Characteristics of Sjögren’s Syndrome and Its Differences from Keratoconjunctivitis Sicca”. Marmara Medical Journal, vol. 34, no. 2, 2021, pp. 208-14, doi:10.5472/marumj.944279.
Vancouver Taskıran I, Kalyoncu U, Kıraz S. Clinical and biochemical characteristics of Sjögren’s syndrome and its differences from keratoconjunctivitis sicca. Marmara Med J. 2021;34(2):208-14.