Comparison of pregnancy and implantation rates in fresh embryo transfer (ET) and frozen-thawed ET cycles in infertile women with polycystic ovarian syndrome.

Joo, Jong Kil; Jo, Moo Sung; Kim, Seung Chul; Choi, Jong Ryeol; Ko, Gyoung Rae; Lee, Kyu Sup

doi:2010.53.4.339

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Obstet Gynecol Sci > Volume 53(4); 2010 > Article

Original Article

Korean Journal of Obstetrics & Gynecology 2010;53(4):339-345.
DOI: https://doi.org/10.5468/kjog.2010.53.4.339 Published online April 1, 2010.

Comparison of pregnancy and implantation rates in fresh embryo transfer (ET) and frozen-thawed ET cycles in infertile women with polycystic ovarian syndrome.

Jong Kil Joo, Moo Sung Jo, Seung Chul Kim, Jong Ryeol Choi, Gyoung Rae Ko, Kyu Sup Lee

¹Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Korea. kuslee@pusan.ac.kr
²Clinic of Infertility, Pusan National University Hospital, Busan, Korea.

Abstract

OBJECTIVE
Aim of this study is to evaluate the pregnancy and implantation rates in fresh-embryo transfer (ET) and frozen-thawed ET cycles in women with polycystic ovarian syndrome (PCOS). METHODS: PCOS was diagnosed by the Rotterdam criteria. In 4 cases of 72 stimulation cycles, ET was not conducted due to severe ovarian hyperstimulation syndrome (OHSS). Sixty eight cycles of fresh-ET and 40 cycles of frozen-thawed ET were included in this retrospective study. Age, gravidity, body mass index, infertility duration were compared between two groups. Number of embryos transferred, implantation rate, clinical pregnancy rate and multiple pregnancy rate were compared between two groups by using chi-square test and student's t-test. RESULTS: Number of embryos transferred showed significant difference between two groups. Fresh-ET group was 4.7 and frozen-thawed ET group was 2.8 (P<0.001). However, overall clinical outcomes with fresh-ET and frozen-thawed ET cycles were similar. Implantation rates were 8.3% vs 11.5%, clinical pregnancy rates were 27.9% vs 25.0% and multiple pregnancy rates were 36.8% vs 20.0%. CONCLUSION: Although more number of embryos were transferred in fresh-ET cycles, the clinical outcomes were similar between fresh-ET and frozen-thawed ET cycles. It may be due to decreased uterine receptivity in fresh-ET cycles. Frozen-thawed ET may be used as alternative plan for cases of severe OHSS and decreased uterine receptivity expected.

Key Words: Polycystic ovarian syndrome, Fresh cycle, Frozen-thawed cycle

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