Autoantibodies associated with neuropsychiatric systemic lupus erythematosus: the quest for symptom-specific biomarkers

Shuzo Sato; Jumpei Temmoku; Yuya Fujita; Makiko Yashiro-Furuya; Naoki Matsuoka; Tomoyuki Asano; Hiroko Kobayashi; Hiroshi Watanabe; Kiyoshi Migita

doi:10.5387/fms.2020-02

Review

Autoantibodies associated with neuropsychiatric systemic lupus erythematosus: the quest for symptom-specific biomarkers

Shuzo Sato, Jumpei Temmoku, Yuya Fujita, Makiko Yashiro-Furuya, Naoki Matsuoka, Tomoyuki Asano, Hiroko Kobayashi, Hiroshi Watanabe, Kiyoshi Migita

Author information

Shuzo Sato
Department of Rheumatology, Fukushima Medical University School of Medicine
Jumpei Temmoku
Department of Rheumatology, Fukushima Medical University School of Medicine
Yuya Fujita
Department of Rheumatology, Fukushima Medical University School of Medicine
Makiko Yashiro-Furuya
Department of Rheumatology, Fukushima Medical University School of Medicine
Naoki Matsuoka
Department of Rheumatology, Fukushima Medical University School of Medicine
Tomoyuki Asano
Department of Rheumatology, Fukushima Medical University School of Medicine
Hiroko Kobayashi
Department of Rheumatology, Fukushima Medical University School of Medicine
Hiroshi Watanabe
Department of Rheumatology, Fukushima Medical University School of Medicine
Kiyoshi Migita
Department of Rheumatology, Fukushima Medical University School of Medicine

Keywords: autoantibody, biomarker, neuropsychiatric systemic lupus erythematosus, pathogenesis, symptom-specific

JOURNAL OPEN ACCESS FULL-TEXT HTML

2020 Volume 66 Issue 1 Pages 1-9

DOI https://doi.org/10.5387/fms.2020-02

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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs, including the central nervous system. Neuropsychiatric SLE (NPSLE) is a severe and potentially fatal condition. Several factors including autoantibodies have been implicated in the pathogenesis of NPSLE. However, definitive biomarkers of NPSLE are yet to be identified owing to the complexity of this disease. This is a major barrier to accurate and timely diagnosis of NPSLE. Studies have identified several autoantibodies associated with NPSLE;some of these autoantibodies are well investigated and regarded as symptom-specific. In this review, we discuss recent advances in our understanding of the manifestations and pathogenesis of NPSLE. In addition, we describe representative symptom-specific autoantibodies that are considered to be closely associated with the pathogenesis of NPSLE.

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