Short Reports
Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation
Authors:
- Alexander C. BertalovitzEmail Alexander C. Bertalovitz
- Milly S. Pau
- Shujuan Gao
- Craig C. Malbon
- Hsien-yu Wang
Abstract
The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin.
- Year: 2016
- Volume: 11
- Page/Article: 1
- DOI: 10.5334/1750-2187-11-1
- Published on 5 Feb 2016
- Peer Reviewed