Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1234

Vollmann, Arabel ; Vornlocher, Hans-Peter ; Stempfl, Thomas ; Brockhoff, Gero ; Apfel, Rainer ; Bogdahn, Ulrich

PDF
(452kB) - Nur für Mitarbeiter des Archivs

Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:26

Alternative Links zum Volltext:Pubmed Verlag

Details

Bibliographische Daten exportieren

Zusammenfassung

The epidermal growth factor receptor (EGFR, ErbB1) is frequently dysregulated in a variety of solid human tumors, including malignant glioma. EGFR expression has been associated with disease progression, resistance to standard therapies and poor survival. The application of small interfering RNAs (siRNAs) has become an effective and highly specific tool to modulate gene expression, and a wide ...