lulab/RBPgroup: RBPgroup
Description
To define a unified, confident binding sites for the RNA community, we developed a non-negative matrix factorization (NMF) method, RBPgroup.
RBPgroup classifies RBPs and related RNA binding sites into co-binding groups. The idea behind this is that the co-binding of multiple RBPs in a RBP complex (i.e. HNRNP splicing complex) would generate more confident binding sites. To realize this idea, we developed a fine-tuned quality control pipeline followed by NMF, which allowed one RBP grouped into different clusters. We adapted this soft-clustering method because one RBP could co-bind with different co-factors to play different regulatory roles.
Files
lulab/RBPgroup-1.0.zip
Files
(30.5 MB)
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Additional details
Related works
- Is supplement to
- https://github.com/lulab/RBPgroup/tree/1.0 (URL)