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Published December 25, 2020 | Version v1
Journal article Open

Relationship between Luteinizing Hormone/Follicle Stimulating Hormone Ratio and Body Mass Index in Women with Polycystic Ovarian Syndrome

  • 1. Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Benin City, Edo State, Nigeria
  • 2. Department of Medical Laboratory Science, College of Natural and Applied Sciences, Achievers University, Owo, Ondo State, Nigeria

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ABSTRACT

Background: The use of luteinizing hormone to follicle-stimulating hormone (LH/FSH) ratio in the diagnosis of polycystic ovarian syndrome (PCOS) is controversial. Objective: To correlate LH/FSH ratio with body mass index (BMI) among women with PCOS, and the possible use of LH/FSH ratio as predictive diagnostic tool of PCOS. Materials and Methods: Serum LH and FSH were assayed by the Enzyme-linked Immunosorbent assay (ELISA) technique using reagents supplied by Monobind, USA. Students-t-test was used to compare the mean values of LH, FSH, and LH/FSH ratio between cases and controls. Pearson correlation was used to associate a measured variable with age and body mass index (BMI). Results: The mean LH and FSH levels were significantly higher (p<0.001) among the infertile women with PCOS when compared to the fertile controls. The LH/FSH ratio was significantly higher (p<0.001) among women with PCOS than control subjects. The serum LH and FSH correlated with age (r=0.318,p<0.05; r=0.320, p<0.05) respectively among women with PCOS. There was a significant correlation between LH and BMI but not between FSH and BMI. On the other hand, LH/FSH ratio correlated with both age and BMI (r=0.319, p<0.05; r=0.309, p<0.05) among women with PCOS. Conclusion: The LH: FSH ratio may be considered as a diagnostic index of PCOS in women with infertility.  Further study involving a large population is suggested to ascertain the diagnostic utility of the LH/FSH ratio among Nigeria women with PCOS.

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