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Published August 10, 2018 | Version 2
Dataset Open

Human Peroxisomal Coenzyme A Diphosphatase (NUDT7); A Target Enabling Package

  • 1. Structural Genomics Consortium
  • 2. Derpartment of Organic Chemistry, The Weizmann Institute of Science
  • 3. Department of Chemistry, School of Life Sciences, University of Sussex

Description

In an effort to characterise the human NUDIX family SGC Oxford has expressed recombinant human NUDT7 as part of the SGC chemical probe programme and solved the first crystal structure of this enzyme. This enabled a crystallographic fragment screen which in conjunction with a separate covalent fragment approach yielded a first-in-class small molecule inhibitor of NUDT7 with activity in the single-digit micromolar range in a catalytic assay. This compound paves the way for chemical probe development and further functional exploration of NUDT7 in physiological and disease contexts.

Notes

This document represents version 2 of the TEP datasheet and includes all updates on the project as of April 2019. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.

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NUDT7_TEP_datasheet_v2.pdf

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Additional details

Related works

Funding

ULTRA-DD – Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery 115766
European Commission