«KING OF PROBIOTICS» BACILLUS COAGULANS IN MODERN COMBINED PROBIOTIC PREPARATIONS LAKTOVIT FORTE (FULL REVIEW)

Bacillus coagulans has an advantage over most other
bacteria used as probiotics. It occupies an intermediate
position between the genera Bacillusand Lactobacillus, is
a spore-forming bacteria that produce lactic acid.This
bacteria in the spores form can tolerate well technology
processes, resistant to antibiotics and antiseptics, does not
collapse under the influence of gastric juice and bile.
Getting into the duodenum, the spores germinate into
vegetative forms and begin vegetation and growth,
providing probiotic effects.Bacillus coagulansrefers to
semi-residental bacteria - performing in the human probiotic
function, it passes the sporulation phase and slowly
leaves the body, standing out in the faeces in the spores
form. Thus, it does not violate the personal composition
of intestinal microflora.Probiotic Bacillus coagulans
enhances the microbiological composition of the intestine,
increasing the number of obligate microorganisms and
displacing pathogenic flora. Mechanisms of this action
based on the lactic acid production and some bacteriocins
synthesis, also on the immunomodulatory effect - stimulation
of cellular and humoral immunity. The bacterial cell
wall and spores are the main immunomodulatory compounds
of the Bacillus coagulans.Apparently, namely
Bacillus coagulans immunomodulatory properties play a
crucial role in the pharmacological effects. It is now well
known about the important role of immune system in the
pathogenesis of many diseases; it has the clinical effect
without the need for intensive growth of bacteria and
intestinal colonization; even small amounts of spores are
sufficient for pharmacological effect; many experimental
evidences of the spore penetration into the lymphatic
system and interaction with immunocompetent cells, as
well as local and systemic immune effects of probiotic.In
addition to this main action, Bacillus coagulans helps to
digest lactose, possesses anti-inflammatory and antioxidant
activity, as well as the cholesterol-lowering effect.
The effectiveness of probiotics, containing spores of
Bacillus coagulans, was confirmed by evidence-based
medicine. Probiotic effect in the treatment of various
diarrheas, including those related to antibiotic treatment,
enterocolitis and irritable bowel syndrome. Bacillus coagulans
application reduces the duration of diarrhea,
reduces the severity of abdominal pain, and normalizes
the composition of intestinal microflora.Bacillus coagulans
efficiency is identified also as hypocholesterolemic
agents, as a means of anti-inflammatory effect in the
combination therapy of arthritis, in combination with soya
extracts for reducing menopause symptoms; by topical
application it was effective in vaginitis, stomatitis and
dental caries. In clinical studies proved the high safety of
probiotics. Except spores Bacillus coagulans, as part of
the “Laktovit Forte” there are also present B9 and B12
vitamins in high doses, which are an essential component
for the early spore’s vegetation in the large intestine.
These vitamins stimulation phenomenon vegetation dispute
has been confirmed experimentally, as shown in the
clinic acceleration by 1-2 days of initial clinical manifestations
of the effects of Bacillus coagulans, which is quite
critical in acute diarrhea microbial origin, abdominal pain
and cramps.