Antitumor Activity of Tinospora cordifolia Bark Extract Against Dalton's Lymphoma Ascites In Swiss Albino Mice
- 1. Biotechnology Department, Udaya School of Engineering, Nagercoil, Tamilnadu, INDIA
- 2. Ariva Med Data Infotech Pvt Ltd., Technopark, Trivandrum, Kerala, INDIA
- 3. Biotechnology Department, BCIL, Banglore, INDIA
- 4. Biotechnology Department, Dr N.G.P Arts and Science College, Coimbatore, Tamilnadu, INDIA
Description
ABSTRACT:
Different parts of Tinospora cordifolia plant products are employed in the Indian traditional medicine for the treatment of several disorders. Our aim was to investigate the cytotoxicity, Antitumor activity and Antioxidant status of Tinospora cordifolia against Daltons Lymphoma Ascites in Swiss Albino Mice. Oral administration of Ethanolic and Water extract of Tinospora cordifolia at a dose of 800 mg/kg body weight each showed an increase in Life span. The ethanolic extract of Tinospora cordifolia showed more effect than water extract and was much comparable to that of 5-flurouracil (standard drug). Our results indicate that Ethanolic extract of Tinospora cordifolia has a prominent Antioxidant and Antitumor activity in experimental DLA bearing mice and can there for be used as an alternative remedy for the treatment of cancer and its complication, due to its lesser or no side effect.
Key words: Tinospora cordifolia, Dalton’s Lymphoma Ascites, Antitumor activity, ethanolic extract, water extract, Swiss Albino mice
http://www.ijbst.org/Home/papers-published/ijbst-2010-volume-3-issue-5
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IJBST_2010_3_5_55-60.pdf
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