Effect of treatment with atypical drugs for 6 months on brain levels of N-acetyl aspartate or serum levels of brain-derived neurotrophic factor in early-stage first-episode schizophrenia - a preliminary study

Naoki Goto; Reiji Yoshimura; Shingo Kakeda; Joji Nishimura; Junji Moriya; Kenji Hayashi; Hikaru Hori; Atsuko Ikenouchi-Sugita; Wakako Umene-Nakano; Asuka Katsuki; Kiyokazu Atake; Yukunori Korogi; Jun Nakamura

doi:10.5234/cnpt.2.34

Original Contribution

Effect of treatment with atypical drugs for 6 months on brain levels of N-acetyl aspartate or serum levels of brain-derived neurotrophic factor in early-stage first-episode schizophrenia - a preliminary study

Naoki Goto, Reiji Yoshimura, Shingo Kakeda, Joji Nishimura, Junji Moriya, Kenji Hayashi, Hikaru Hori, Atsuko Ikenouchi-Sugita, Wakako Umene-Nakano, Asuka Katsuki, Kiyokazu Atake, Yukunori Korogi, Jun Nakamura

Author information

Naoki Goto
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health
Reiji Yoshimura
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health
Shingo Kakeda
Department of Radiology, School of Medicine, University of Occupational and Environmental Health
Joji Nishimura
Department of Radiology, School of Medicine, University of Occupational and Environmental Health
Junji Moriya
Department of Radiology, School of Medicine, University of Occupational and Environmental Health
Kenji Hayashi
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health
Hikaru Hori
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health
Atsuko Ikenouchi-Sugita
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health
Wakako Umene-Nakano
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health
Asuka Katsuki
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health
Kiyokazu Atake
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health
Yukunori Korogi
Department of Radiology, School of Medicine, University of Occupational and Environmental Health
Jun Nakamura
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health

Keywords: N-acetyl aspartate, brain-derived neurotrophic factor, magnetic resonance spectroscopy, schizophrenia, atypical antipsychotic drug

JOURNAL FREE ACCESS

2011 Volume 2 Pages 34-42

DOI https://doi.org/10.5234/cnpt.2.34

Details

Abstract

In the present study, we investigated the effects of atypical antipsychotic drugs on brain NAA and serum BDNF levels in early-stage first-episode schizophrenia patients. Sixteen (8 males, 8 females; mean age: 30 ± 11 yr) of 18 patients were followed for 6 months. All patients were treated with atypical antipsychotic drugs. No changes in NAA concentrations in the three regions were observed from before treatment to 6 months after atypical psychotic treatment. In addition, serum BDNF levels also did not change from before to 6 months after treatment. These preliminary results suggest that relatively short-term treatment with atypical antipsychotic drugs may be unlikely to alter brain NAA concentrations and serum BDNF levels in early-stage first-episode schizophrenia.

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