Open Access, Peer-reviewed
pISSN 2234-8646
eISSN 2234-8840
    Korean J Pediatr Gastroenterol Nutr. 2011 Dec;14(Suppl 1):S42-S46. Korean.
    Published online Dec 31, 2011.
    https://doi.org/10.5223/kjpgn.2011.14.Suppl1.S42
    Copyright © 2011 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
    Review

    Stem Cell in Pediatric Gastrointestinal Tract Disease: Hirschsprung Disease

    Sun Hwan Bae, M.D., Ph.D.
      • Department of Pediatrics, Konkuk University School of Medicine, Seoul, Korea.
    • Corresponding author (Email: baedori@hanafos.com )
    Received December 24, 2011; Revised December 29, 2011; Accepted December 29, 2011.

    Abstract

    Stem cell is characterized with self-renewal and mult-potency. Many pediatric gastrointestinal diseases have defect in enterocytes, enteric nervous system, and Interstitial cell of Cajal. Various kinds of stem cell could be applied to these diseases. Here, the author introduces stem cell for pediatric gastrointestinal diseases, particularly Hirschsprung disease.

    Keywords
    Stem cell; Hirschsprung disease

    Figures

    Fig. 1
    Lineage tracing in the small intestine confirms intestinal stem cells. In this case, LacZ activity was used as a reporter gene8).

    Fig. 2
    Neurons from transplanted neurospheres regulate the contractility of developing gut. EMNS and NHNS transplanted bowel have comparable contraction frequencies to ganglionic distal colon, but have significantly lower contraction frequencies than aganglionic distal colon, demonstrating a functional effect of neurosphere transplantation18). EMNS: aganglionic distal colon transplanted with embryonic mouse neurosphere, NHNS: aganglionic distal colon transplanted with neonatal human neurosphere, TTX: tetrodotoxin.

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    MeSH Terms
    Enteric Nervous System
    Enterocytes
    Gastrointestinal Diseases
    Gastrointestinal Tract
    Hirschsprung Disease
    Stem Cells
    Metrics
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