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Authors: Cheng-Liang Peng 1 ; Yuan-I Chen 2 ; Ying-Hsia Shih 1 ; Tsai-Yueh Luo 1 and Ming-Jium Shieh 2

Affiliations: 1 Institute of Nuclear Energy Research, Taiwan ; 2 National Taiwan University, Taiwan

Keyword(s): Thermosensitive, Photothermal Therapy, Chemotherapy, Micelle, Control Release, Synergistic Effect.

Related Ontology Subjects/Areas/Topics: Bioimaging ; Biomedical Engineering ; Medical Imaging and Diagnosis

Abstract: Multifunctional theranostics have recently been intensively explored to optimize the efficacy and safety. Herein, we report multifunctional micelle that constructed from graft copolymer PEGMA-co-PDPA and diblock copolymer mPEG-b-PCL as the carrier of hydrophobic photosensitizer, chlorin e6 (Ce6) for simultaneous fluorescence imaging and photodynamic therapy. The functional inner core of PEGMA-co-PDPA exhibited pH stimulate to accelerate drug release under slightly acidic microenvironments of tumors and the outer shell of micelles with epidermal growth factor receptor (EGFR)-targeting GE11 peptides for active targeting of EGFR-overexpressing cancer cells. The results demonstrate that GE11-conjugated chlorin e6-loaded micelles (GE11-Ce6-micelles) with particle size around 100 nm and the micelles had well defined core shell structure which was evaluated by TEM. In the in vitro cellular uptake studies, GE11-Ce6-micelles exhibited a higher amount of intracellular uptake of chlorin e6 in H CT116 cancer cells (EGFR high expression) via receptor-mediated endocytosis, in contrast with the time-dependent passive uptake of the non-targeted Ce6-micelles, thereby providing a effective photocytotoxic effect on the HCT116 cancer cells. In vivo study revealed that GE11-Ce6-micelles exhibited tumor targeting for photodynamic detection and excellent inhibition on tumor growth after irradiation, indicating that GE11-Ce6-micelles could be successfully applied to the effective fluorescence imaging and photodynamic therapy of cancer. (More)

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Paper citation in several formats:
Peng, C.; Chen, Y.; Shih, Y.; Luo, T. and Shieh, M. (2016). EGFR-targeting Peptide Conjugated pH-sensitive Micelles as a Potential Drug Carrier for Photodynamic Detection and Therapy of Cancer. In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016) - BIOIMAGING; ISBN 978-989-758-170-0; ISSN 2184-4305, SciTePress, pages 105-110. DOI: 10.5220/0005774201050110

@conference{bioimaging16,
author={Cheng{-}Liang Peng. and Yuan{-}I Chen. and Ying{-}Hsia Shih. and Tsai{-}Yueh Luo. and Ming{-}Jium Shieh.},
title={EGFR-targeting Peptide Conjugated pH-sensitive Micelles as a Potential Drug Carrier for Photodynamic Detection and Therapy of Cancer},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016) - BIOIMAGING},
year={2016},
pages={105-110},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005774201050110},
isbn={978-989-758-170-0},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016) - BIOIMAGING
TI - EGFR-targeting Peptide Conjugated pH-sensitive Micelles as a Potential Drug Carrier for Photodynamic Detection and Therapy of Cancer
SN - 978-989-758-170-0
IS - 2184-4305
AU - Peng, C.
AU - Chen, Y.
AU - Shih, Y.
AU - Luo, T.
AU - Shieh, M.
PY - 2016
SP - 105
EP - 110
DO - 10.5220/0005774201050110
PB - SciTePress