ABSTRACT

The aim of this study is to evaluate the effects of the levonorgestrel-releasing intrauterine system (LR-IUS) on endometrial thickness, hemogram parameters, and uterine artery Doppler results among women who have endometrial hyperplasia without atypia.

Fifty-four women who admitted to our hospital due to menorrhagia and with a diagnosis of endometrial hyperplasia without atypia treated with the LR-IUS were included in our study. The uterine artery measurements, uterine volume, alterations on hemoglobin concentrations, and follow-up endometrial biopsies after 6 months were analyzed.

Fifty women completed the 6-month period. Among all these women, regression was recorded in endometrial hyperplasia. The uterine artery resistance index, pulsatility index, and uterine volume did not show any significant difference. Reduction in the endometrial thickness and increasing levels of hemoglobin and hematocrit concentrations were also determined.

LR-IUS may be used as an effective procedure and a confident alternative medical approach to oral gestagen therapy and surgery among women with menorrhagia who have simple endometrial hyperplasia without atypia.

Keywords: LR-IUS, uterine artery, resistance index, pulsatility index, power Doppler, endometrial hyperplasia