İstanbul Journal of Pharmacy

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DOI :10.5152/IstanbulJPharm.2017.002   IUP :10.5152/IstanbulJPharm.2017.002    Full Text (PDF)

Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides

Bahar Ulus Karaca, Müzeyyen Çeliksöz Akar, Gül Özhan

Human populations are exposed to several toxic substances in the environment, including pesticides. Fenoxaprop-p-ethyl (FPE) and fluzifob-p-butyl (FPB) herbicides are extensively used in agricultural fields due to their high target selectivity and low non-target toxicity. They are known as aryloxyphenoxypropionate herbicides, and acetyl-CoA carboxylase inhibitor. In the study, we aimed to evaluate the toxic potentials of FPE and FPB herbicides. Cell viability was evaluated by MTT assay in the range of 15.6-500.0 µM exposure concentrations in mouse fibroblast (BALB/3T3) cell line. Also, we investigated their DNA damage potentials on BALB/3T3 cells by using alkaline Comet assay. The results indicated that FPE and FPB showed no evidence of DNA damage. And, the cell viability was more than 20% at 12.5-400 µM exposure concentrations. FPE and FPB might be safe according to our results and the previously studies, and there would be public health benefits from encouraging its use in the place of more toxic herbicide products. 

Keywords: Fenoxaprop-p-ethyl, fluzifob-p-butyl, 3T3 cells

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APA

Ulus Karaca, B., Çeliksöz Akar, M., & Özhan, G. (2017). Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides. İstanbul Journal of Pharmacy, 47(1), 5-8. https://doi.org/10.5152/IstanbulJPharm.2017.002


AMA

Ulus Karaca B, Çeliksöz Akar M, Özhan G. Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides. İstanbul Journal of Pharmacy. 2017;47(1):5-8. https://doi.org/10.5152/IstanbulJPharm.2017.002


ABNT

Ulus Karaca, B.; Çeliksöz Akar, M.; Özhan, G. Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides. İstanbul Journal of Pharmacy, [Publisher Location], v. 47, n. 1, p. 5-8, 2017.


Chicago: Author-Date Style

Ulus Karaca, Bahar, and Müzeyyen Çeliksöz Akar and Gül Özhan. 2017. “Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides.” İstanbul Journal of Pharmacy 47, no. 1: 5-8. https://doi.org/10.5152/IstanbulJPharm.2017.002


Chicago: Humanities Style

Ulus Karaca, Bahar, and Müzeyyen Çeliksöz Akar and Gül Özhan. “Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides.” İstanbul Journal of Pharmacy 47, no. 1 (May. 2024): 5-8. https://doi.org/10.5152/IstanbulJPharm.2017.002


Harvard: Australian Style

Ulus Karaca, B & Çeliksöz Akar, M & Özhan, G 2017, 'Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides', İstanbul Journal of Pharmacy, vol. 47, no. 1, pp. 5-8, viewed 19 May. 2024, https://doi.org/10.5152/IstanbulJPharm.2017.002


Harvard: Author-Date Style

Ulus Karaca, B. and Çeliksöz Akar, M. and Özhan, G. (2017) ‘Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides’, İstanbul Journal of Pharmacy, 47(1), pp. 5-8. https://doi.org/10.5152/IstanbulJPharm.2017.002 (19 May. 2024).


MLA

Ulus Karaca, Bahar, and Müzeyyen Çeliksöz Akar and Gül Özhan. “Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides.” İstanbul Journal of Pharmacy, vol. 47, no. 1, 2017, pp. 5-8. [Database Container], https://doi.org/10.5152/IstanbulJPharm.2017.002


Vancouver

Ulus Karaca B, Çeliksöz Akar M, Özhan G. Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides. İstanbul Journal of Pharmacy [Internet]. 19 May. 2024 [cited 19 May. 2024];47(1):5-8. Available from: https://doi.org/10.5152/IstanbulJPharm.2017.002 doi: 10.5152/IstanbulJPharm.2017.002


ISNAD

Ulus Karaca, Bahar - Çeliksöz Akar, Müzeyyen - Özhan, Gül. “Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides”. İstanbul Journal of Pharmacy 47/1 (May. 2024): 5-8. https://doi.org/10.5152/IstanbulJPharm.2017.002



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Accepted24.03.2017

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