Research Article


DOI :10.5152/IstanbulJPharm.2017.0016   IUP :10.5152/IstanbulJPharm.2017.0016    Full Text (PDF)

Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov

Sevda Süzgeç SelçukNurten ÖzsoyBerna Özbek ÇelikEmine Akalın Uruşak

Ferulago W. Koch is a genus in the Apiaceae family comprising 34 species, of which 18 are endemic in Turkey. Ferulago species have been known since the time of Dioscorides and have been used in folk medicine for their sedative, tonic, digestive, carminative, and aphrodisiac effects, as well as for the treatment of intestinal worms and hemorrhoids. This study was conducted to evaluate the polyphenolic contents and antioxidant activities of methanol extracts of the aerial parts (HFT) and rhizomes (RFT) of Ferulago trojana E. Akalın & Pimenov by measuring their ability to inhibit lipid peroxidation induced by Fe3+-ascorbate, their DPPH· and ABTS·+ scavenging activities, and their ferric reducing antioxidant power (FRAP value). The methanol extracts were also examined for their antimicrobial activity using the microbroth dilution technique. Results showed that the methanol extracts of the aerial parts of the plant, containing the highest amount of total phenolic content and flavonoids, exhibited antioxidative potential for the chain-breaking inhibition of lipid peroxidation and showed the strongest hydrogen and single electron donor activities, which could thus serve as a free radical scavenger, act as a reductant, and provide protection against oxidative stress. Although the methanol extract of rhizomes did not exhibit any inhibitory effect on lipid peroxidation, it is possible that it might also have protective effects against oxidative damage by scavenging free radicals and acting as a reductant. While both the methanol extracts of the aerial parts and rhizomes of F. trojana were effective against Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), and S. epidermidis, the extracts showed no activity against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. In addition, the methanol extract of rhizomes of F. trojana exhibited antibacterial activity against Proteus mirabilis and antifungal activity against the yeast Candida albicans. 


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APA

Süzgeç Selçuk, S., Özsoy, N., Özbek Çelik, B., & Akalın Uruşak, E. (2017). Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov. İstanbul Journal of Pharmacy, 47(3), 101-106. https://doi.org/10.5152/IstanbulJPharm.2017.0016


AMA

Süzgeç Selçuk S, Özsoy N, Özbek Çelik B, Akalın Uruşak E. Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov. İstanbul Journal of Pharmacy. 2017;47(3):101-106. https://doi.org/10.5152/IstanbulJPharm.2017.0016


ABNT

Süzgeç Selçuk, S.; Özsoy, N.; Özbek Çelik, B.; Akalın Uruşak, E. Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov. İstanbul Journal of Pharmacy, [Publisher Location], v. 47, n. 3, p. 101-106, 2017.


Chicago: Author-Date Style

Süzgeç Selçuk, Sevda, and Nurten Özsoy and Berna Özbek Çelik and Emine Akalın Uruşak. 2017. “Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov.” İstanbul Journal of Pharmacy 47, no. 3: 101-106. https://doi.org/10.5152/IstanbulJPharm.2017.0016


Chicago: Humanities Style

Süzgeç Selçuk, Sevda, and Nurten Özsoy and Berna Özbek Çelik and Emine Akalın Uruşak. Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov.” İstanbul Journal of Pharmacy 47, no. 3 (Apr. 2024): 101-106. https://doi.org/10.5152/IstanbulJPharm.2017.0016


Harvard: Australian Style

Süzgeç Selçuk, S & Özsoy, N & Özbek Çelik, B & Akalın Uruşak, E 2017, 'Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov', İstanbul Journal of Pharmacy, vol. 47, no. 3, pp. 101-106, viewed 24 Apr. 2024, https://doi.org/10.5152/IstanbulJPharm.2017.0016


Harvard: Author-Date Style

Süzgeç Selçuk, S. and Özsoy, N. and Özbek Çelik, B. and Akalın Uruşak, E. (2017) ‘Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov’, İstanbul Journal of Pharmacy, 47(3), pp. 101-106. https://doi.org/10.5152/IstanbulJPharm.2017.0016 (24 Apr. 2024).


MLA

Süzgeç Selçuk, Sevda, and Nurten Özsoy and Berna Özbek Çelik and Emine Akalın Uruşak. Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov.” İstanbul Journal of Pharmacy, vol. 47, no. 3, 2017, pp. 101-106. [Database Container], https://doi.org/10.5152/IstanbulJPharm.2017.0016


Vancouver

Süzgeç Selçuk S, Özsoy N, Özbek Çelik B, Akalın Uruşak E. Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov. İstanbul Journal of Pharmacy [Internet]. 24 Apr. 2024 [cited 24 Apr. 2024];47(3):101-106. Available from: https://doi.org/10.5152/IstanbulJPharm.2017.0016 doi: 10.5152/IstanbulJPharm.2017.0016


ISNAD

Süzgeç Selçuk, Sevda - Özsoy, Nurten - Özbek Çelik, Berna - Akalın Uruşak, Emine. Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov”. İstanbul Journal of Pharmacy 47/3 (Apr. 2024): 101-106. https://doi.org/10.5152/IstanbulJPharm.2017.0016



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Accepted08.12.2017

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