Dong Hyeok Cha; Seon Kyeong Kim; Hyo Jeong Kim; Naria Lee; Hyeong Seok Nam; Bo Gwang Choi; Hye Won Lee; Seong Geun Kim; Young Jin Choi; Joo Seop Chung; Goon Jae Cho

doi:10.5045/kjh.2009.44.3.144

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Cha, Kim, Kim, Lee, Nam, Choi, Lee, Kim, Choi, Chung, and Cho: A Case of Acute Myeloblastic Leukemia in a Patient with Behçet's Disease

Case Report

Korean J Hematol 2009;44(3):144-147.

Published online: 20 September 2009

DOI: https://doi.org/10.5045/kjh.2009.44.3.144

A Case of Acute Myeloblastic Leukemia in a Patient with Behçet's Disease

Dong Hyeok Cha, M.D., Seon Kyeong Kim, M.D., Hyo Jeong Kim, M.D., Naria Lee, M.D., Hyeong Seok Nam, M.D., Bo Gwang Choi, M.D., Hye Won Lee, M.D., Seong Geun Kim, M.D., Young Jin Choi, M.D., Joo Seop Chung, M.D., Goon Jae Cho, M.D.

Department of Internal Medicine, School of Medicine, Pusan National University, Busan, Korea

Correspondence to：Young-Jin Choi, MD Departments of Internal Medicine, School of Medicine, Pusan National University 1-10, Ami-dong, Seo-gu, Busan 602-739, Korea Tel: ＋82-51-240-7225, Fax: ＋82-51-254-3127 E-mail: chyj@pusan.ac.kr

Received 6 March 2009 Revised 20 August 2009 Accepted 20 August 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Behçet's disease is a relapsing inflammatory disorder characterized by vasculitis of unknown cause and has been reported rarely in association with malignant diseases. In most cases the autoimmune nature of Behçet's disease and the long-term immunosuppressive therapy for disease control have been proposed to be responsible for malignant transformation. Although a few cases of various solid tumor and myelodys-plastic syndrome have been reported in association with Behçet's disease, acute leukemia has seldom been associated with Behçet's disease in Korea. We report a case of 38-year-old man with acute myeloblastic leukemia association with a Behçet's disease who had not received long-term treatment.

Keywords: Behçet's disease, Acute myeloblastic leukemia

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Fig. 1.

The bone marrow aspirate shows myeloblastic cells (Wright Giemsa ×1,000).

Fig. 2.

The bone marrow biopsy shows myeloblastic cells (H&E ×100).

Fig. 3.

The karyogram shows hyperdiploidy clones (arrows), 52, XY,+8, +10, +12, +18, +21, +22.

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