Journal List > Korean J Hematol > v.42(3) > 1032731

Nam, Cho, Yang, Son, and Jeon: Therapeutic Efficacy of a Single Dose of Anti-D Immunoglobulin 50μg/kg in Childhood Acute Immune Thrombocytopenic Purpura

Abstract

Background:

To investigate the efficacy and adverse effects of a single dose of anti-D immunoglobulin (50μg/kg) in Korean children with acute immune thrombocytopenic purpura (ITP).

Methods:

We serially evaluated the platelet count in 21 acute ITP patients that were treated with anti-D immunoglobulin (50μg/kg) to determine how many patients achieved platelet counts over the levels of 20×103/mm3, 50×103/mm3 and 100×103/mm3 after the infusion of anti-D immunoglobulin. In addition, constitutional symptoms were monitored and changes in the hemoglobin levels were serially evaluated.

Results:

By three days after treatment, 90.5% of the patients had achieved a platelet count over 20× 103/mm3. At seven days after treatment, 66.7% of patients achieved a platelet count of 50×103/mm3. In addition, at seven days after treatment 61.9% of patients achieved a platelet count of 100×103/mm3. Constitutional adverse symptoms were observed 61.9% of patients, and the symptoms diminished spontaneously without any severe sequelaes. The decline of hemoglobin concentration after treatment recovered to the initial level after two weeks.

Conclusion:

A single dose of anti-D immunoglobulin (50μg/kg)was effective in Korean children with acute ITP to raise the platelet count rapidly. The adverse effects of anti-D immunoglobulin, including hemolytic anemia, were not severe to prevent the use of the anti-D.

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Fig. 1
Rate of platelet response over 20×103/mm3 per time in patients treated with anti-D. Values in whole bar (□ ■) and black portion (■) indicate the total subjects and the subjects who showed platelet count over 20× 103/mm3, respectively.
kjh-42-258f1.tif
Fig. 2
Rate of platelet response over 50×103/mm3 per time in patients treated with anti-D. Values in whole bar (□ ■) and black portion (■) indicate the total subjects and the subjects who showed platelet count over 50× 103/mm3, respectively.
kjh-42-258f2.tif
Fig. 3
Rate of platelet response over 100×103/mm3 per time in patients treated with anti-D. Values in whole bar (□■) and black portion (■) indicate the total subjects and the subjects who showed platelet count over 100× 103/mm3, respectively.
kjh-42-258f3.tif
Fig. 4
The frequency of constitutional adverse symptoms by anti-D.
kjh-42-258f4.tif
Fig. 5
Changes in hemoglobin values after anti-D infusion.
kjh-42-258f5.tif
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