Open Access, Peer-reviewed
pISSN 2093-4378
eISSN 2093-4386
    J Korean Soc Spine Surg. 2008 Jun;15(2):102-105. Korean.
    Published online Jun 30, 2008.
    https://doi.org/10.4184/jkss.2008.15.2.102
    Copyright © 2008 Korean Society of Spine Surgery
    Case Report

    Multidrug-resistant Tuberculosis Spondylitis - A Case Report -

    Sung Chan Ki, M.D., Ki Soo Kim, M.D., Yoon Hong Kim, M.D. and Yong Soo Choi, M.D.
      • Department of Orthopedic Surgery, Kwang-ju Christian Hospital, Gwang-Ju, South Korea.
    • Address reprint requests to: Yong Soo Choi, M.D. Department of Orthopaedic Surgery, Kwangju Christian Hospital, 264 Yang-lim dong, Nam-gu, Gwangju,503-715, Korea. Tel: 82-62-650-5060, Fax: 82-62-650-5066, Email: stemcellchoi@yahoo.co.kr

    Abstract

    Multidrug-resistant tuberculosis, resistant to at least isoniazid and rifampicin, continues to present a serious challenge to human health. However, there are no reports addressing multidrug-resistant tuberculous spondylitis in Korea. We report a case of multidrug-resistant tuberculous spondylitis at L2-L3 in a 30-year-old woman.

    Keywords
    Tuberculosis spondylitis; Multidrug resistance

    Figures

    Fig. 1
    Preoperative radiographs and MR Imaging. (A) Radiographs show destruction of vertebral body and kyphotic deformity (Sagittal index: 40 degrees) at L2-3. (B) Sagittal T1 and T2-weighted imaging of L2-3 demonstrate destruction of vertebral bodies and compression of dural sacs. Axial T2-weighted images show the abscess formation at psoas muscle, right.

    Fig. 2
    Histologic finding shows caseous necrosis with chronic granulated inflammation (H-E×100).

    Fig. 3
    Radiographs and MR Imaging at 26months after the operation. (A) Radiographs show collapse of grafted bone, destruction of vertebral bodies and kyphotic deformity at L2-4. (B) Sagittal T1 and T2-weighted imaging of L2-4 demonstrate destruction of vertebral bodies and severe compression of dural sacs. Axial T2-weighted images show the large abscess formation at psoas muscle and fistula formation, right.

    Fig. 4
    Tuberculosis drug sensitivity test result in drug-resistant for Isoniazid, Rifampicin and Streptomycin.

    Fig. 5
    Radiographs at 18months after 2nd operation show well bony fusion at L2-3-4.

    References

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    MeSH Terms
    Adult
    Drug Resistance, Multiple
    Humans
    Isoniazid
    Korea
    Rifampin
    Spondylitis
    Tuberculosis
    Tuberculosis, Multidrug-Resistant
    Metrics
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