Open Access, Peer-reviewed
pISSN 2093-4378
eISSN 2093-4386
    J Korean Soc Spine Surg. 2001 Sep;8(3):372-377. Korean.
    Published online Sep 30, 2001.
    https://doi.org/10.4184/jkss.2001.8.3.372
    Copyright © 2001 Korean Society of Spine Surgery
    Review

    Growth Factors and Their Clinical Applications

    Seong-Hwan Moon, M.D., Hak-Sun Kim, M.D. and Hwan-Mo Lee, M.D.
      • Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.
    • Address reprint requests to Seong-Hwan Moon, M.D. Department of Orthopaedic Surgery, Yonsei University College of Medicine, #134 Shinchon-dong, Soedaemun-gu, Seoul 120-752, Korea. Tel: 82-2-361-5649, Fax: 82-2-363-1139, Email: shmoon@yumc.yonsei.ac.kr

    Abstract

    Growth factor is a polypeptide regulating cell proliferation, maturation, activity, and apoptosis. Despite its small molecular weight, it exerts diverse and potent biologic effects on cellular function. With recent development of molecular biology and vector technology, it is now possible to administer recombinant growth factors in clinical dose and modify somatic cell with growth factor encoding gene. Research fields in spinal surgery can be divided into spinal fusion, disc regeneration and spinal cord regeneration. In this review, we discuss the action mechanism of growth factors and their possible clinical applications especially in the field of spinal fusion and disc regeneration.

    Keywords
    Growth factor; Spinal fusion; Disc degeneration

    Tables

    Table 1
    Abbreviation used in the text

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    MeSH Terms
    Apoptosis
    Cell Proliferation
    Fibrinogen
    Intercellular Signaling Peptides and Proteins*
    Intervertebral Disc Degeneration
    Molecular Biology
    Molecular Weight
    Regeneration
    Spinal Cord Regeneration
    Spinal Fusion
    Metrics
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