Open Access, Peer-reviewed
pISSN 2288-0402
eISSN 2288-0410
    Allergy Asthma Respir Dis. 2015 Jan;3(1):35-39. Korean.
    Published online Jan 31, 2015.
    https://doi.org/10.4168/aard.2015.3.1.35
    © 2015 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology
    Original Article

    Relationship between serum 25-hydroxyvitamin D and lung function among Korean adults

    Young Wook Kim,1 Dong Soo Ryu,2 and Ju Suk Lee3
      • 1Department of Occupational and Environmental Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
      • 2Department of Urology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
      • 3Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
    • Correspondence to: Ju Suk Lee. Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, 158 Paryong-ro, Masanhoewon-gu, Changwon 630-723, Korea. Tel: +82-55-290-6045, Fax: +82-55-290-6044, Email: ljs8952194@lycos.co.kr
    Received June 26, 2014; Revised October 05, 2014; Accepted October 18, 2014.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

    Abstract

    Purpose

    The relationship between vitamin D status and pulmonary function has been investigated in several studies. But previous study results are controversial. We want to know the relationship between vitamin D status and pulmonary function in Korean adults in small regional area.

    Methods

    The medical records of 3,253 subjects were reviewed retrospectively, those visited for routine health examination in Samsung Changwon Hospital between January and December 2013. All of them were workers in one company and lived in one island ('Geojedo').

    Results

    Vitamin D deficiency group (serum 25-hydroxyvitamin D [25(OH)D]<20 ng/mL) showed lowed % forced vital capacity in one second (%FEV1; P<0.01), forced vital capacity (FVC; P<0.01) and higher FEV1/FVC (P<0.01). Serum 25(OH)D was positively correlated with %FEV1 (R=0.035, P<0.05), %FVC (R=0.081, P<0.01), FVC (R=0.125, P<0.01) and negatively with FEV1/FVC (R=-0.083, P<0.01). After adjustment for smoking history, we found serum 25(OH)D level was positively correlated with %FVC (R=0.058, P<0.01), FVC (R=0.093, P<0.01) and negatively with FEV1/FVC (R=-0.055, P<0.01). After adjustment for smoking and asthma history, we found serum 25(OH)D level was positive correlated with %FVC (R=0.103, P<0.01) and negatively with FEV1/FVC (R=-0.119, P<0.01).

    Conclusion

    Serum 25(OH)D level was associated with pulmonary function.

    Keywords
    Vitamin D; Respiratory function tests; Forced expiratory volume

    Tables

    Table 1
    Clinical characteristics of vitamin D deficiency subjects

    Table 2
    Lung function by serum 25(OH)D deficiency in subjects

    Table 3
    Relationship of serum vitamin D and lung function

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    MeSH Terms
    Adult*
    Asthma
    Forced Expiratory Volume
    Gyeongsangnam-do
    Humans
    Lung*
    Medical Records
    Respiratory Function Tests
    Retrospective Studies
    Smoke
    Smoking
    Vital Capacity
    Vitamin D
    Vitamin D Deficiency
    Metrics
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