Open Access, Peer-reviewed
pISSN 2288-0402
eISSN 2288-0410
    Allergy Asthma Respir Dis. 2013 Jun;1(2):172-175. Korean.
    Published online Jun 27, 2013.
    https://doi.org/10.4168/aard.2013.1.2.172
    © 2013 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology
    Case Report

    Anaphylaxis caused by muscle relaxant (eperisone hydrochloride)

    Sung Hyun Kim, Jaechun Lee, Su Hee Kim, Hyun Woo Kim, Young Uck Kim, Younghyup Lim, Shinhang Moon, Jaecheol Moon and Dahee Heo
      • Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
    • Correspondence to: Jaechun Lee. Department of Internal Medicine, Jeju National University School of Medicine, 102 Jejudaehak-ro, Jeju 690-756, Korea. Tel: +82-64-754-3915, Fax: +82-64-725-2593, Email: doc4u@hanmail.net
    Received March 20, 2013; Revised April 12, 2013; Accepted April 12, 2013.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

    Abstract

    Eperisone hydrochloride is an antispasmodic drug, decreasing spasticity of skeletal muscle and alleviating stiffness, and as a consequence, controlling pain. It is preferably prescribed with other analgesics, beneficially less decreasing alertness compared with other antispasmodics. Its fatal drug adverse reactions were rarely reported. A 70 year-old female with hives, swollen face, hoarse voice, and near fainting admitted via emergency department. She suffered from the series of the fatal symptoms after administration of the pills, prescribed for her neck pain. Two months before, she had experienced hives on similar medications. At presentation, she revealed hypoxemia and hypotension, and treated with epinephrine, glucocorticoids and antihistamines. Among the medicines she took, eperisone hydrochloride was proven as the causative medicine and others were excluded in oral provocation tests. The positive result in intradermal test with eperisone hydrochloride suggested immediate-type hypersensitivity reaction. We report a case of anaphylaxis to eperisone hydrochloride, one of the widely prescribed medicines in clinical practice, previously without awareness of drug adverse reaction.

    Keywords
    Anaphylaxis; Eperisone; Muscle relaxants; Immediate hypersensitivity; Drug hypersensitivity

    Figures

    Fig. 1
    Generalized hives with periorbital and neck angioedema developed in 30 minutes after oral administration of eperisone hydrochloride 25 mg in oral provocation test.

    Fig. 2
    Intradermal tests with eperisone hydrochloride and saline as a negative control. 11 mm×9 mm sized wheal reaction was observed at intradermal injection of eperisone hydrochloride (E). No wheal was seen in saline (-).

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    MeSH Terms
    Analgesics
    Anaphylaxis
    Anoxia
    Drug Hypersensitivity
    Emergencies
    Epinephrine
    Female
    Glucocorticoids
    Histamine Antagonists
    Humans
    Hypersensitivity
    Hypersensitivity, Immediate
    Hypotension
    Intradermal Tests
    Muscle Spasticity
    Muscle, Skeletal
    Muscles
    Neck Pain
    Parasympatholytics
    Propiophenones
    Syncope
    Urticaria
    Voice
    Metrics
    Share
    Figures
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