Open Access, Peer-reviewed
pISSN 2288-0402
eISSN 2288-0410
    Allergy Asthma Respir Dis. 2013 Mar;1(1):67-72. Korean.
    Published online Mar 31, 2013.
    https://doi.org/10.4168/aard.2013.1.1.67
    © 2013 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology
    Original Article

    The association between sibling and allergic rhinitis in adolescents

    Ju-Hee Seo,1 Hyung Young Kim,2 Young-Ho Jung,3 Ji-Won Kwon,4 Byoung-Ju Kim,5 Hyo-Bin Kim,6 Woo Kyung Kim,7 So-Yeon Lee,8 Gwang Cheon Jang,9 Dae Jin Song,10 Jung Yeon Shim,11 Eun-Jin Kim,12 Joo-Shil Lee,12 and Soo-Jong Hong3
      • 1Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea.
      • 2Department of Pediatrics, Kosin University Gospel Hospital, Busan, Korea.
      • 3Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
      • 4Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
      • 5Department of Pediatrics, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
      • 6Department of Pediatrics, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
      • 7Department of Pediatrics, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
      • 8Department of Pediatrics, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
      • 9Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
      • 10Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
      • 11Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea.
      • 12Department of Immunology and Pathology, Allergy TF, Korea National Institute of Health, Cheongwon, Korea.
    • Correspondence to: Soo-Jong Hong. Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea. Tel: +82-2-3010-3379, Fax: +82-2-473-3725, Email: sjhong@amc.seoul.kr
    Received August 31, 2012; Revised February 26, 2013; Accepted February 26, 2013.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

    Abstract

    Purpose

    We investigated the effect of siblings on the development of allergic rhinitis (AR) in Korean adolescents.

    Methods

    A cross-sectional study of adolescents (n=3,271) aged 12 to 15 years was conducted at three middle schools in Seoul. Demographic and disease-related information was obtained through a questionnaire.

    Results

    The mean age of the subjects was 13.9±0.8 years comprising 48.7% males and 51.3% females. The percentage of the subjects who had ever been diagnosed with AR by physician was 30.7%. Subjects who had older sibling and who had younger sibling were 45.3% and 44.2% respectively. Subjects with older sibling were less likely to diagnose AR than subjects without older sibling (adjusted odds ratio [aOR], 0.69; 95% confidence interval [CI], 0.57 to 0.84). Subjects with older sibling, even though with family history of allergic disease had protective effect compared to subjects without older sibling (aOR, 0.62; 95% CI, 0.45 to 0.84). Subjects with younger sibling were more likely to diagnose AR than subjects without younger sibling (aOR, 1.23; 95% CI, 1.02 to 1.49).

    Conclusion

    These findings suggest that having older sibling is one of the important protective factor for the development of allergic rhinitis and having younger sibling is risk factor for allergic rhinitis in adolescents.

    Keywords
    Allergic rhinitis; Adolescent; Sibling

    Tables

    Table 1
    General characteristics

    Table 2
    Prevalence of allergic rhinitis

    Table 3
    Analysis of allergic rhinitis diagnosis according to older, younger sibling

    Table 4
    Analysis of allergic rhinitis diagnosis according to the parental allergic diseases and older sibling

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    MeSH Terms
    Adolescent
    Aged
    Cross-Sectional Studies
    Female
    Humans
    Male
    Odds Ratio
    Rhinitis
    Rhinitis, Allergic, Perennial
    Risk Factors
    Siblings
    Metrics
    Share
    Tables
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