Drug Induced Liver Injury by Prophylactic Administration of Albendazole

Sang Yi Moon; Yang Hyun Baek; Sung Wook Lee

doi:10.4166/kjg.2019.73.6.360

Journal List > Korean J Gastroenterol > v.73(6) > 1128276

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Moon, Baek, and Lee: Drug Induced Liver Injury by Prophylactic Administration of Albendazole

Case Report

The Korean Journal of Gastroenterology 2019; 73(6): 360-364.

Published online: 27 June 2019

DOI: https://doi.org/10.4166/kjg.2019.73.6.360

Drug Induced Liver Injury by Prophylactic Administration of Albendazole

Sang Yi Moon, Yang Hyun Baek, Sung Wook Lee

Division of Gastroenterology, Department of Internal Medicine, Dong-A University Hospital, Busan, Korea.

Correspondence to: Sung Wook Lee, Division of Gastroenterology, Department of Internal Medicine, Dong-A University Hospital, 26 Daesingongwon-ro, Seo-gu, Busan 49201, Korea. Tel: +82-51-240-5042, Fax: +82-51-242-5852, E-mail: sunglee@dau.ac.kr

Received 23 November 2018 Revised 7 February 2019 Accepted 8 February 2019

Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Albendazole is used as a typical antiparasitic agent worldwide. The side effects of albendazole may include nausea, vomiting, abdominal pain, dizziness, headache, alopecia, and increased liver enzymes. Mild elevation of the liver enzyme has been reported in more than 10% of cases, but drug induced liver injury was reported to be very rare. A 30-year-old woman visited the Dong-A University Hospital with anorexia, nausea, jaundice, and elevated liver enzyme. For diagnosis, other acute hepatitis etiologies were excluded, but the prophylactic administration of albendazole was verified. This paper introduces a case of drug-induced liver injury through the prophylactic administration of albendazole. Physicians should be aware of severe liver injury as one of the side effects of albendazole.

Keywords: Albendazole, Drug induced liver injury

Figures and Tables

Fig. 1

Change in the laboratory findings while in episode 1. (A) Aminotransferase. (B) Total/direct bilirubin. AST, aspartate aminotransferase; ALT, alanine aminotransferase.

Fig. 2

Change in the laboratory findings while in episode 2. (A) Aminotransferase. (B) Total/direct bilirubin. AST, aspartate aminotransferase; ALT, alanine aminotransferase.

Notes

^{Financial support} None.

^{Conflict of interest} None.

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ORCID iDs: Sung Wook Lee
https://orcid.org/0000-0001-9243-8488
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