Journal List > Korean J Gastroenterol > v.63(2) > 1007199

Jeon and Cheung: Clinical Improvement of Los Angeles Grade D Esophagitis with Proton Pump Inhibitor

References

1. Kahrilas PJ. Clinical practice. Gastroesophageal reflux disease. N Engl J Med. 2008; 359:1700–1707.
2. Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013; 108:308–328.
crossref
3. Armstrong D. Review article: gastric pH–the most relevant pre-dictor of benefit in reflux disease? Aliment Pharmacol Ther. 2004; 20(Suppl 5):19–26.
4. Katz PO, Ginsberg GG, Hoyle PE, Sostek MB, Monyak JT, Silberg DG. Relationship between intragastric acid control and healing status in the treatment of moderate to severe erosive oesophagitis. Aliment Pharmacol Ther. 2007; 25:617–628.
crossref
5. Katz PO, Johnson DA, Levine D, et al. A model of healing of Los Angeles grades C and D reflux oesophagitis: is there an optimal time of acid suppression for maximal healing? Aliment Pharmacol Ther. 2010; 32:443–447.
crossref
6. Khan M, Santana J, Donnellan C, Preston C, Moayyedi P. Medical treatments in the short term management of reflux oesophagitis. Cochrane Database Syst Rev. 2007; 2:CD003244.
7. Carlsson R, Dent J, Watts R, et al. Gastro-oesophageal reflux disease in primary care: an international study of different treatment strategies with omeprazole. International GORD Study Group. Eur J Gastroenterol Hepatol. 1998; 10:119–124.
8. Dent J, Brun J, Fendrick AM, et al. An evidence-based appraisal of reflux disease management–the Genval Workshop Report. Gut. 1999; 44(Suppl 2):S1–S16.

Fig. 1.
Esophagogastroduodenoscopy shows diffuse and coalesced circular ulcer expanding from gastroesophageal junction to mid-esophagus (22 cm from incisor). Spotty red pigmentations with thick whitish exudates are present at the ulcer base.
kjg-63-134f1.tif
Fig. 2.
Follow-up esophagogastroduodenoscopy performed after one month. Previously noted circumferential ulcer that extended from mid to lower eso-phagus has almost completely healed, and the ulcer base is now covered with friable and thin regenerative epithe-lium. Focal erosion near Z-line can be seen.
kjg-63-134f2.tif
Fig. 3.
Follow-up esophagogastroduodenoscopy performed seven months later. Blurred Z-line with focal mucosal breaks less than 5 mm is observed. Short segment of lower esophageal stricture due to healing scar of pre-vious reflux esophagitis can also be noted.
kjg-63-134f3.tif
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